OBJECTIVE: To determine to what extent the clinical response to methylphenidate (MPH) is affected by psychiatric comorbidities in children diagnosed with attention-deficit hyperactivity disorder (ADHD). METHODS:Children (n = 267) aged 6 to 12 years diagnosed with ADHD participated in a double-blind, placebo-controlled, 2-week medication trial of MPH. Children were assessed using parent and teacher ratings and laboratory measures. Clinical response to MPH was determined by integrating all obtained measures. RESULTS: Meeting criteria for conduct disorder (CD) was 27.7% of children, 40.8% for oppositional defiant (ODD), 47.2% for anxiety, and 7.9% for depressive disorders. The presence of CD or ODD was associated with good response to MPH. In contrast, children diagnosed with only comorbid anxiety were more likely to receive poor response rating independent of age, sex, or socioeconomic status. Low family income was found to be predictive of good response to MPH. CONCLUSIONS: The response to MPH in children with ADHD may be dependent on the type of comorbid disorder present. CLINICAL TRIAL REGISTRATION NUMBER: NCT00483106.
RCT Entities:
OBJECTIVE: To determine to what extent the clinical response to methylphenidate (MPH) is affected by psychiatric comorbidities in children diagnosed with attention-deficit hyperactivity disorder (ADHD). METHODS:Children (n = 267) aged 6 to 12 years diagnosed with ADHD participated in a double-blind, placebo-controlled, 2-week medication trial of MPH. Children were assessed using parent and teacher ratings and laboratory measures. Clinical response to MPH was determined by integrating all obtained measures. RESULTS: Meeting criteria for conduct disorder (CD) was 27.7% of children, 40.8% for oppositional defiant (ODD), 47.2% for anxiety, and 7.9% for depressive disorders. The presence of CD or ODD was associated with good response to MPH. In contrast, children diagnosed with only comorbid anxiety were more likely to receive poor response rating independent of age, sex, or socioeconomic status. Low family income was found to be predictive of good response to MPH. CONCLUSIONS: The response to MPH in children with ADHD may be dependent on the type of comorbid disorder present. CLINICAL TRIAL REGISTRATION NUMBER: NCT00483106.
Authors: A Moreno; L Duñó; E Hoekzema; M Picado; L M Martín; J Fauquet; Y Vives-Gilabert; A Bulbena; O Vilarroya Journal: Eur Child Adolesc Psychiatry Date: 2014-01-07 Impact factor: 4.785
Authors: Nour Al Ghriwati; Joshua M Langberg; William Gardner; James Peugh; Kelly J Kelleher; Rebecca Baum; William B Brinkman; Phil Lichtenstein; Jeffery N Epstein Journal: J Dev Behav Pediatr Date: 2017-01 Impact factor: 2.225
Authors: Catherine G Coughlin; Stephanie C Cohen; Jilian M Mulqueen; Eduardo Ferracioli-Oda; Zachary D Stuckelman; Michael H Bloch Journal: J Child Adolesc Psychopharmacol Date: 2015-09-24 Impact factor: 2.576
Authors: Ole Jakob Storebø; Erica Ramstad; Helle B Krogh; Trine Danvad Nilausen; Maria Skoog; Mathilde Holmskov; Susanne Rosendal; Camilla Groth; Frederik L Magnusson; Carlos R Moreira-Maia; Donna Gillies; Kirsten Buch Rasmussen; Dorothy Gauci; Morris Zwi; Richard Kirubakaran; Bente Forsbøl; Erik Simonsen; Christian Gluud Journal: Cochrane Database Syst Rev Date: 2015-11-25