Literature DB >> 20481554

Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages.

Emily C Barker1, Tonibelle N Gatbonton-Schwager, Yong Han, Jennifer E Clay, John J Letterio, Gregory P Tochtrop.   

Abstract

Bryonolic acid (BA) is a triterpenoid found in the Cucurbitaceae family of plants. Our interests in the immunomodulatory effects of this class of natural products led us to discover that BA induces a marked increase in the expression of a phase 2 response enzyme, heme oxygenase 1 (HO-1), in a dose-dependent manner. This phenotype has translational implications in malarial disease progression, and consequently we developed a large-scale isolation method for BA that will enable future in vitro and in vivo analyses. We have determined ideal growth conditions and time scale for maximizing BA content in the roots of Cucurbita pepo and analyzed BA production by HPLC. Large-scale extraction yielded 1.34% BA based on dry weight, allowing for the isolation of BA on a multigram scale.

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Year:  2010        PMID： 20481554      PMCID： PMC2905313          DOI： 10.1021/np1000076

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  20 in total

1.  Anti-allergic effect of bryonolic acid from Luffa cylindrica cell suspension cultures.

Authors:  S Tanaka; C Uno; M Akimoto; M Tabata; C Honda; W Kamisako
Journal:  Planta Med       Date:  1991-12       Impact factor: 3.352

2.  Novel triterpenoids suppress inducible nitric oxide synthase (iNOS) and inducible cyclooxygenase (COX-2) in mouse macrophages.

Authors:  N Suh; T Honda; H J Finlay; A Barchowsky; C Williams; N E Benoit; Q W Xie; C Nathan; G W Gribble; M B Sporn
Journal:  Cancer Res       Date:  1998-02-15       Impact factor: 12.701

3.  Structure of bryonolic acid.

Authors:  G Biglino; L Cattel; O Caputo
Journal:  Ric Sci       Date:  1969-03

4.  Arbuscular mycorrhizal fungus-promoted accumulation of two new triterpenoids in cucumber roots.

Authors:  Kohki Akiyama; Hideo Hayashi
Journal:  Biosci Biotechnol Biochem       Date:  2002-04       Impact factor: 2.043

5.  Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines.

Authors:  T Akihisa; H Tokuda; E Ichiishi; T Mukainaka; M Toriumi; M Ukiya; K Yasukawa; H Nishino
Journal:  Cancer Lett       Date:  2001-11-08       Impact factor: 8.679

6.  Relative population of S-form and F-form conformers of bryonolic acid and its derivatives in equilibrium in CdCl3 solutions.

Authors:  Chie Honda; Kiyoko Suwa; Shizuyo Takeyama; Wasuke Kamisako
Journal:  Chem Pharm Bull (Tokyo)       Date:  2002-04       Impact factor: 1.645

7.  Production of an anti-allergic triterpene bryonolic acid, by plant cell cultures.

Authors:  M Tabata; S Tanaka; H J Cho; C Uno; J Shimakura; M Ito; W Kamisako; C Honda
Journal:  J Nat Prod       Date:  1993-02       Impact factor: 4.050

8.  Heme oxygenase-1 affords protection against noncerebral forms of severe malaria.

Authors:  Elsa Seixas; Raffaella Gozzelino; Angelo Chora; Ana Ferreira; Gabriela Silva; Rasmus Larsen; Sofia Rebelo; Carmen Penido; Neal R Smith; Antonio Coutinho; Miguel P Soares
Journal:  Proc Natl Acad Sci U S A       Date:  2009-08-17       Impact factor: 11.205

9.  Bryonolic acid production in hairy roots of Trichosanthes kirilowii Max. var Japonica Kitam. Transformed with Agrobacterium rhizogenes and its cytotoxic activity.

Authors:  T Takeda; T Kondo; H Mizukami; Y Ogihara
Journal:  Chem Pharm Bull (Tokyo)       Date:  1994-03       Impact factor: 1.645

10.  Cytotoxic activity of bryonolic acid isolated from transformed hairy roots of Trichosanthes kirilowii var. japonica.

Authors:  T Kondo; M Inoue; H Mizukami; Y Ogihara
Journal:  Biol Pharm Bull       Date:  1995-05       Impact factor: 2.233
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  4 in total

1.  Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

Authors:  Tonibelle N Gatbonton-Schwager; John J Letterio; Gregory P Tochtrop
Journal:  J Nat Prod       Date:  2012-02-16       Impact factor: 4.050

2.  Balanced cytokine upregulation by diluted ethanolic extract of Bryonia alba in Delta SARS-CoV-2 Spike protein RBD-induced pathogenesis in Gallus gallus embryo.

Authors:  Pritam Goswami; Debasmita Chatterjee; Sayak Ghosh; Krishnendu Paira; Satadal Das
Journal:  Bull Natl Res Cent       Date:  2022-06-13

3.  Molecular library synthesis using complex substrates: expanding the framework of triterpenoids.

Authors:  Vasily A Ignatenko; Yong Han; Gregory P Tochtrop
Journal:  J Org Chem       Date:  2013-01-10       Impact factor: 4.354

4.  The effects of methanolic, chloroform, and ethylacetate extracts of the Cucurbita pepo L. on the delay type hypersensitivity and antibody production.

Authors:  A Jafarian; B Zolfaghari; M Parnianifard
Journal:  Res Pharm Sci       Date:  2012-10
  4 in total

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