OBJECTIVE: To investigate association of TIM1 sequence variations with HIV/AIDS progression. INTRODUCTION: : HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response. MATERIALS AND METHODS: We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplotypes. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated. RESULTS: Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4 cell count (P = 0.06) and lower proportion of AIDS-related symptoms (P = 0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P = 0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1. CONCLUSION: TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females.
OBJECTIVE: To investigate association of TIM1 sequence variations with HIV/AIDS progression. INTRODUCTION: : HIV-1 infected individuals have wide variations in disease progression including AIDS. T cell immunoglobulin and mucin 1 (TIM1) is a cell surface protein involved in the regulation of Th1/Th2 immune response. MATERIALS AND METHODS: We sequenced the highly polymorphic exon 4 of TIM1 from 246 individuals of HIV-1 infected Thai female cohort to determine their TIM1 haplotypes. Associations of TIM1 haplotypes with baseline clinical data (sero-status, plasma viral load, CD4 cell count, and symptomatic AIDS) and survival status during 3 years of follow-up were evaluated. RESULTS: Seven TIM1 haplotypes, D3-A, D4, D3-C, D1, W-A, W-C, and D3-C*, were found in the cohort. Patients possessing the D3-A haplotype showed trends towards higher CD4 cell count (P = 0.06) and lower proportion of AIDS-related symptoms (P = 0.022) than the other patients at the baseline. Kaplan-Meier analysis demonstrated that patients carrying the D3-A haplotype had a better survival rates (P = 0.019) than the others. D3-A haplotypes was tightly linked to the lower expression levels of TIM1. CONCLUSION:TIM1 D3-A haplotype is associated with the delay of disease progression to AIDS in the HIV-1 infected Thai females.
Authors: Hye Young Kim; Ya-Jen Chang; Ya-Ting Chuang; Hyun-Hee Lee; David I Kasahara; Thomas Martin; Joyce T Hsu; Paul B Savage; Stephanie A Shore; Gordon J Freeman; Rosemarie H Dekruyff; Dale T Umetsu Journal: J Allergy Clin Immunol Date: 2013-05-11 Impact factor: 10.793
Authors: N Tsuchiya; P Pathipvanich; A Rojanawiwat; N Wichukchinda; I Koga; M Koga; W Auwanit; P E Kilgore; K Ariyoshi; P Sawanpanyalert Journal: Epidemiol Infect Date: 2012-11-01 Impact factor: 2.451
Authors: Alex Olvera; Javier P Martinez; Maria Casadellà; Anuska Llano; Míriam Rosás; Beatriz Mothe; Marta Ruiz-Riol; Gemma Arsequell; Gregorio Valencia; Marc Noguera-Julian; Roger Paredes; Andreas Meyerhans; Christian Brander Journal: Front Immunol Date: 2018-01-26 Impact factor: 7.561