Literature DB >> 20478557

Synthesis and biological evaluation of glycal-derived novel tetrahydrofuran 1,2,3-triazoles by 'click' chemistry.

L Vijaya Raghava Reddy1, P Venkat Reddy, Nripendra N Mishra, Praveen K Shukla, Garima Yadav, Ranjana Srivastava, Arun K Shaw.   

Abstract

Thirteen new 1,2,3-triazoles (5a-e, 15a-d, 17a-b, 19, and 21) were synthesized by 'click' reaction of sugar-derived azides with commercially available acetylenes. The synthesized triazoles were tested in vitro for their biological activity, and compound 5b displayed both antibacterial and antifungal activities at an MIC value of 12.5 microg/mL, while compounds 15b and 19 showed antibacterial activity at an MIC value of 25 microg/mL. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20478557     DOI： 10.1016/j.carres.2010.03.031

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN： 0008-6215            Impact factor:   2.104


  4 in total

1.  Targeting tuberculosis through a small focused library of 1,2,3-triazoles.

Authors:  Guillermo R Labadie; Agustina de la Iglesia; Héctor R Morbidoni
Journal:  Mol Divers       Date:  2011-06-02       Impact factor: 2.943

2.  Crystal structure of 1-(4-fluoro-phen-yl)-4-(4-meth-oxy-phen-yl)-1H-1,2,3-triazole.

Authors:  Balbir Kumar; Madhvi Bhardwaj; Satya Paul; Rajni Kant; Vivek K Gupta
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2015-07-04

3.  Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production.

Authors:  Sándor B Otvös; Adám Georgiádes; István M Mándity; Lóránd Kiss; Ferenc Fülöp
Journal:  Beilstein J Org Chem       Date:  2013-07-29       Impact factor: 2.883

4.  The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker.

Authors:  Iwona E Głowacka; Jan Balzarini; Andrzej E Wróblewski
Journal:  Eur J Med Chem       Date:  2013-10-30       Impact factor: 6.514
  4 in total

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