Literature DB >> 20476790

Polyketide assembly by alkene-alkyne reductive cross-coupling: spiroketals through the union of homoallylic alcohols.

Daniel P Canterbury1, Glenn C Micalizio.   

Abstract

A reaction sequence composed of regioselective formal hydroalkynylation, reductive ene-yne cross-coupling, and oxidative cyclization has been developed to prepare stereochemically dense spiroketals. Overall, the chemistry defines a three-component coupling process for the union of two homoallylic alcohol-based substrates with trimethylsilylacetylene.

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Year:  2010        PMID： 20476790      PMCID： PMC2892691          DOI： 10.1021/ja102888f

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  18 in total

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  8 in total

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3.  Enantioselective synthesis of anti- and syn-homopropargyl alcohols via chiral Brønsted acid catalyzed asymmetric allenylboration reactions.

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4.  The Development of Alkoxide-Directed Metallacycle-Mediated Annulative Cross-Coupling Chemistry.

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8.  Enantiospecific Alkynylation of Alkylboronic Esters.

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  8 in total

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