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Literature DB >> 20473302

Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.

Zsuzsanna Izsvák¹, Janine Fröhlich, Ivana Grabundzija, James R Shirley, Heather M Powell, Karen M Chapman, Zoltán Ivics, F Kent Hamra.

Abstract

Disrupting genes in the rat on a genome-wide scale will allow the investigation of many biological processes linked to human health. Here we used transposon-mediated mutagenesis to knock out genes in rat spermatogonial stem cells. Given the capacity of the testis to support spermatogenesis from thousands of transplanted, genetically manipulated spermatogonia, this approach paves a way for high-throughput functional genomic studies in the laboratory rat.

Entities: CellLine Chemical Disease Gene Species

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Year: 2010 PMID： 20473302 PMCID： PMC2886193 DOI： 10.1038/nmeth.1461

Source DB: PubMed Journal: Nat Methods ISSN： 1548-7091 Impact factor: 28.547

15 in total

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Authors: Kyle E Orwig; Takashi Shinohara; Mary R Avarbock; Ralph L Brinster
Journal: Biol Reprod Date: 2002-04 Impact factor: 4.285

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Authors: Kazuhiro Kitada; Satoshi Ishishita; Keiko Tosaka; Ri-ichi Takahashi; Masatsugu Ueda; Vincent W Keng; Kyoji Horie; Junji Takeda
Journal: Nat Methods Date: 2007-01-14 Impact factor: 28.547

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Journal: Proc Natl Acad Sci U S A Date: 2005-11-17 Impact factor: 11.205

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Authors: Z Ivics; P B Hackett; R H Plasterk; Z Izsvák
Journal: Cell Date: 1997-11-14 Impact factor: 41.582

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Authors: Buom-Yong Ryu; Hiroshi Kubota; Mary R Avarbock; Ralph L Brinster
Journal: Proc Natl Acad Sci U S A Date: 2005-09-23 Impact factor: 11.205

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Authors: Mario R Capecchi
Journal: Nat Rev Genet Date: 2005-06 Impact factor: 53.242

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Authors: Baisong Lu; Aron M Geurts; Christophe Poirier; Deborah C Petit; Wilbur Harrison; Paul A Overbeek; Colin E Bishop
Journal: Mamm Genome Date: 2007-06-08 Impact factor: 2.957

9. Production of transgenic rats by lentiviral transduction of male germ-line stem cells.

Authors: F Kent Hamra; Joel Gatlin; Karen M Chapman; Dana M Grellhesl; J Victor Garcia; Robert E Hammer; David L Garbers
Journal: Proc Natl Acad Sci U S A Date: 2002-10-21 Impact factor: 11.205

10. Sterile testis complementation with spermatogonial lines restores fertility to DAZL-deficient rats and maximizes donor germline transmission.

Authors: Timothy E Richardson; Karen M Chapman; Christina Tenenhaus Dann; Robert E Hammer; F Kent Hamra
Journal: PLoS One Date: 2009-07-21 Impact factor: 3.240

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Journal: Nat Protoc Date: 2011-05-26 Impact factor: 13.491

3. Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.

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Journal: Nat Protoc Date: 2011-09-08 Impact factor: 13.491

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Authors: F Kent Hamra
Journal: Nature Date: 2010-09-09 Impact factor: 49.962

5. Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.

Authors: Zoltán Ivics; Zsuzsanna Izsvák; Karen M Chapman; F Kent Hamra
Journal: Methods Date: 2010-12-28 Impact factor: 3.608

6. Germline modification of domestic animals.

Authors: L Tang; R González; I Dobrinski
Journal: Anim Reprod Date: 2015 Jan-Mar Impact factor: 1.807

Review 7. Rat placentation: an experimental model for investigating the hemochorial maternal-fetal interface.

Authors: M J Soares; D Chakraborty; M A Karim Rumi; T Konno; S J Renaud
Journal: Placenta Date: 2012-01-28 Impact factor: 3.481

8. Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats.

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Journal: Transgenic Res Date: 2011-10-15 Impact factor: 2.788

9. TALEN-mediated gene targeting in porcine spermatogonia.

Authors: Lin Tang; Alla Bondareva; Raquel González; Jose R Rodriguez-Sosa; Daniel F Carlson; Dennis Webster; Scott Fahrenkrug; Ina Dobrinski
Journal: Mol Reprod Dev Date: 2018-02-22 Impact factor: 2.609

10. Viral transduction of male germline stem cells results in transgene transmission after germ cell transplantation in pigs.

Authors: Wenxian Zeng; Lin Tang; Alla Bondareva; Ali Honaramooz; Valeria Tanco; Camila Dores; Susan Megee; Mark Modelski; Jose Rafael Rodriguez-Sosa; Melissa Paczkowski; Elena Silva; Matt Wheeler; Rebecca L Krisher; Ina Dobrinski
Journal: Biol Reprod Date: 2013-01-31 Impact factor: 4.285