Literature DB >> 17220894

Transposon-tagged mutagenesis in the rat.

Kazuhiro Kitada1, Satoshi Ishishita, Keiko Tosaka, Ri-ichi Takahashi, Masatsugu Ueda, Vincent W Keng, Kyoji Horie, Junji Takeda.   

Abstract

Although the laboratory rat (Rattus norvegicus) is an indispensable experimental animal for biomedical research and drug development, the lack of embryonic stem cell lines hampers gene-knockout studies. Here we report the successful generation of insertional mutant rats using the Sleeping Beauty (SB) transposon system. This would benefit a variety of biomedical research fields for which the rat model is better suited than the mouse model.

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Year:  2007        PMID： 17220894     DOI： 10.1038/nmeth1002

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  60 in total

1.  Generating gene knockout rats by homologous recombination in embryonic stem cells.

Authors:  Chang Tong; Guanyi Huang; Charles Ashton; Ping Li; Qi-Long Ying
Journal:  Nat Protoc       Date:  2011-05-26       Impact factor: 13.491

2.  Sleeping Beauty transposon mutagenesis in rat spermatogonial stem cells.

Authors:  Zoltán Ivics; Zsuzsanna Izsvák; Gerardo Medrano; Karen M Chapman; F Kent Hamra
Journal:  Nat Protoc       Date:  2011-09-08       Impact factor: 13.491

3.  Sleeping Beauty transposon mutagenesis of the rat genome in spermatogonial stem cells.

Authors:  Zoltán Ivics; Zsuzsanna Izsvák; Karen M Chapman; F Kent Hamra
Journal:  Methods       Date:  2010-12-28       Impact factor: 3.608

4.  Derivation of rat embryonic stem cells and generation of protease-activated receptor-2 knockout rats.

Authors:  Satoshi Yamamoto; Mitsugu Nakata; Reiko Sasada; Yuki Ooshima; Takashi Yano; Tadahiro Shinozawa; Yasuhiro Tsukimi; Michiyasu Takeyama; Yoshio Matsumoto; Tadatoshi Hashimoto
Journal:  Transgenic Res       Date:  2011-10-15       Impact factor: 2.788

5.  Generating knockout rats by transposon mutagenesis in spermatogonial stem cells.

Authors:  Zsuzsanna Izsvák; Janine Fröhlich; Ivana Grabundzija; James R Shirley; Heather M Powell; Karen M Chapman; Zoltán Ivics; F Kent Hamra
Journal:  Nat Methods       Date:  2010-05-16       Impact factor: 28.547

6.  Chromosomal transposition of PiggyBac in mouse embryonic stem cells.

Authors:  Wei Wang; Chengyi Lin; Dong Lu; Zeming Ning; Tony Cox; David Melvin; Xiaozhong Wang; Allan Bradley; Pentao Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-25       Impact factor: 11.205

7.  Efficient transposition of Tol2 in the mouse germline.

Authors:  Vincent W Keng; Barbara J Ryan; Kirk J Wangensteen; Darius Balciunas; Christian Schmedt; Stephen C Ekker; David A Largaespada
Journal:  Genetics       Date:  2009-10-05       Impact factor: 4.562

Review 8.  Size matters: versatile use of PiggyBac transposons as a genetic manipulation tool.

Authors:  Adele Kim; Ilmari Pyykko
Journal:  Mol Cell Biochem       Date:  2011-04-23       Impact factor: 3.396

9.  Transgenesis in Xenopus using the Sleeping Beauty transposon system.

Authors:  Donald A Yergeau; Michelle R Johnson Hamlet; Emin Kuliyev; Haiqing Zhu; Joanne R Doherty; Taylor D Archer; Andrea P Subhawong; Marc B Valentine; Clair M Kelley; Paul E Mead
Journal:  Dev Dyn       Date:  2009-07       Impact factor: 3.780

Review 10.  The biology of infertility: research advances and clinical challenges.

Authors:  Martin M Matzuk; Dolores J Lamb
Journal:  Nat Med       Date:  2008-11-06       Impact factor: 53.440
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