| Literature DB >> 20471838 |
Atul Kumar1, Siddharth Sharma, Vishwa Deepak Tripathi, Ram Awatar Maurya, Swayam Prakash Srivastava, Gitika Bhatia, A K Tamrakar, Arvind Kumar Srivastava.
Abstract
A series of 2,4-disubstituted polyhydroquinoline were synthesized and evaluated for their in vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized compounds have exhibited promising in vivo antihyperglycemic in SLM, STZ-S, and db/db mice model along with significant lipid and TG modulating activity. All these compounds were evaluated in various in vitro models of diabetes to know the possible mechanism of their antihyperglycemic action. Interestingly, compounds 3a-r (diaryl substitution) have exhibited promising protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity whereas, compounds 5a-d (acid substituted) have shown significant glycogen phosphorylase activity.Entities:
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Year: 2009 PMID： 20471838 DOI： 10.1016/j.bmc.2009.11.061
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641