| Literature DB >> 20471698 |
Bin Xing1, Tao Xin, Lingling Zhao, Randy L Hunter, Yan Chen, Guoying Bing.
Abstract
Aberrant microglia activation causes dopaminergic neuronal loss and nitric oxide produced by microglia plays a critical role in dopaminergic neuronal degeneration. However, no study has determined if GDNF protects dopaminergic neurons via inhibiting nitric oxide generation in Parkinson's disease animal model. We report that GDNF not only reduces lipopolysaccharide-induced degeneration of dopaminergic neurons, suppresses microglia activation and nitric oxide generation, but also reverses the inhibition of phosphoinositide 3-kinase (PI3K) in dopaminergic neurons and microglia. It suggests that the neuroprotective effect of GDNF on dopaminergic neurons may be related to its suppression of microglia activation-mediated nitric oxide via releasing the inhibition of PI3K in both neurons and microglia. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20471698 PMCID： PMC2924924 DOI： 10.1016/j.jneuroim.2010.04.010
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478