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Literature DB >> 3239957

Rate of cell death in parkinsonism indicates active neuropathological process.

P L McGeer¹, S Itagaki, H Akiyama, E G McGeer.

Abstract

It has been hypothesized that idiopathic parkinsonism might be due to age-related attrition of dopamine neurons occurring long after an initial acute episode. We present evidence against this hypothesis, based on our finding of at least six times as many HLA-DR-positive microglia phagocytosing dopamine neurons in parkinsonian brains as in control brains. This difference indicates an active pathological process.

Entities: Chemical Disease

Mesh：

Substances：
Glycoproteins
Dopamine

Year: 1988 PMID： 3239957 DOI： 10.1002/ana.410240415

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

Keyword Cloud
Cited

150 in total

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Journal: Mol Ther Date: 2010-06-08 Impact factor: 11.454

2. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Authors: N Takahashi; L L Miner; I Sora; H Ujike; R S Revay; V Kostic; V Jackson-Lewis; S Przedborski; G R Uhl
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

3. Increased binding of 3H-L-deprenyl in spinal cords from patients with amyotrophic lateral sclerosis as demonstrated by autoradiography.

Authors: S M Aquilonius; S S Jossan; J G Ekblom; H Askmark; P G Gillberg
Journal: J Neural Transm Gen Sect Date: 1992

4. Dopamine synthesis in the nigrostriatal system at the presymptomatic and early symptomatic stages in parkinsonian mice.

Authors: G R Khakimova; E A Kozina; A Ya Sapronova; M V Ugrumov
Journal: Dokl Biol Sci Date: 2011-12-02

Review 5. The immunology of neurodegeneration.

Authors: Eva Czirr; Tony Wyss-Coray
Journal: J Clin Invest Date: 2012-04-02 Impact factor: 14.808

Rate of cell death in parkinsonism indicates active neuropathological process.

1. Macrophage-mediated GDNF delivery protects against dopaminergic neurodegeneration: a therapeutic strategy for Parkinson's disease.

2. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

3. Increased binding of 3H-L-deprenyl in spinal cords from patients with amyotrophic lateral sclerosis as demonstrated by autoradiography.

4. Dopamine synthesis in the nigrostriatal system at the presymptomatic and early symptomatic stages in parkinsonian mice.

Review 5. The immunology of neurodegeneration.

6. Biochemical alterations of the striatum in an MPTP-treated mouse model of Parkinson's disease.

7. Lymphocytes reduce nigrostriatal deficits in the 6-hydroxydopamine mouse model of Parkinson's disease.

Review 8. Current theories on the cause of Parkinson's disease.

9. Microglial activation and dopaminergic cell injury: an in vitro model relevant to Parkinson's disease.

Review 10. Innate and adaptive immune responses in Parkinson's disease.