| Literature DB >> 20471440 |
Guo-Lin Bian1, Rui Ma, Hong-Jun Dong, Hong-Xia Ni, Feng-Jiao Hu, Yao-Rong Chen, Jia-Qun Chen, Shao-Ying Zhou, Yong-Xin Lin, Guo-Zhang Xu.
Abstract
110 children who were given the complete course of the inactivated hepatitis A vaccine (Havrix) were followed up 10 years later. Age-matched healthy children who were not inoculated served as controls. One month after two primary injections, all children were positive for serum antibody. After 10 years, 99.09% of inoculated children remained positive for serum anti-HAV antibody, with a geometric mean concentration (GMC) of 61.59mIU/mL. GMC values following a secondary immunization in children with antibody levels <20mIU/mL were significantly elevated (567.9mIU/mL), compared with the primary injection alone. Havrix appears to induce persistent immunity and potent immune memory. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20471440 DOI： 10.1016/j.vaccine.2010.04.096
Source DB: PubMed Journal: Vaccine ISSN： 0264-410X Impact factor: 3.641