BACKGROUND: Obstructive sleep apnea (OSA) is common after stroke and associated with poor stroke outcomes. Whether OSA after acute stroke is caused by anatomic, physiologic, or both etiologies has not been studied. We therefore used brain magnetic resonance imaging (MRI) scans to assess oropharyngeal anatomy in stroke patients with and without OSA. METHODS: Patients within 7 days of ischemic stroke underwent nocturnal polysomnography. Sagittal T1-weighted MRI performed for clinical purposes was used to measure retropalatal distance, soft palatal length, soft palatal thickness, retroglossal space, and tongue length. Nasopharyngeal area and high retropharyngeal area were measured from axial T2-weighted images, and lateral pharyngeal wall thickness from coronal T1-weighted images. RESULTS: Among 27 subjects, 18 (67%) had OSA (apnea/hypopnea index (AHI)5). Demographics, vascular risk factors, and stroke severity were similar in the two groups. Median retropalatal distance was shorter in subjects with OSA (Wilcoxon rank-sum test, p=0.03). Shorter retropalatal distance was associated with higher AHI (linear regression, p=0.04). None of the other morphological characteristics differed. CONCLUSIONS: Anatomic difference between awake acute stroke patients with and without OSA shows that the sleep disorder cannot be attributed solely to sleep, sleeping position, or changes in neuromuscular control that are specific to the sleep state. Copyright 2010 Elsevier B.V. All rights reserved.
BACKGROUND:Obstructive sleep apnea (OSA) is common after stroke and associated with poor stroke outcomes. Whether OSA after acute stroke is caused by anatomic, physiologic, or both etiologies has not been studied. We therefore used brain magnetic resonance imaging (MRI) scans to assess oropharyngeal anatomy in strokepatients with and without OSA. METHODS:Patients within 7 days of ischemic stroke underwent nocturnal polysomnography. Sagittal T1-weighted MRI performed for clinical purposes was used to measure retropalatal distance, soft palatal length, soft palatal thickness, retroglossal space, and tongue length. Nasopharyngeal area and high retropharyngeal area were measured from axial T2-weighted images, and lateral pharyngeal wall thickness from coronal T1-weighted images. RESULTS: Among 27 subjects, 18 (67%) had OSA (apnea/hypopnea index (AHI)5). Demographics, vascular risk factors, and stroke severity were similar in the two groups. Median retropalatal distance was shorter in subjects with OSA (Wilcoxon rank-sum test, p=0.03). Shorter retropalatal distance was associated with higher AHI (linear regression, p=0.04). None of the other morphological characteristics differed. CONCLUSIONS: Anatomic difference between awake acute strokepatients with and without OSA shows that the sleep disorder cannot be attributed solely to sleep, sleeping position, or changes in neuromuscular control that are specific to the sleep state. Copyright 2010 Elsevier B.V. All rights reserved.
Authors: M A Ciscar; G Juan; V Martínez; M Ramón; T Lloret; J Mínguez; M Armengot; J Marín; J Basterra Journal: Eur Respir J Date: 2001-01 Impact factor: 16.671
Authors: O Parra; A Arboix; S Bechich; L García-Eroles; J M Montserrat; J A López; E Ballester; J M Guerra; J J Sopeña Journal: Am J Respir Crit Care Med Date: 2000-02 Impact factor: 21.405
Authors: Richard J Schwab; Michael Pasirstein; Robert Pierson; Adonna Mackley; Robert Hachadoorian; Raanan Arens; Greg Maislin; Allan I Pack Journal: Am J Respir Crit Care Med Date: 2003-05-13 Impact factor: 21.405
Authors: Devin L Brown; Lynda D Lisabeth; Michael J Zupancic; Maryann Concannon; Cory Martin; Ronald D Chervin Journal: Stroke Date: 2008-07-10 Impact factor: 7.914