PURPOSE: To investigate cerebral and cerebellar gray matter abnormalities in patients with first-episode major depressive disorder (MDD). MATERIALS AND METHODS: We examined the structural difference in regional gray matter density (GMD) between 22 first-episode MDD patients and 30 age-, gender- and education-matched healthy controls by optimized voxel-based morphometry (VBM) based on magnetic resonance imaging. RESULTS: Compared with healthy controls, MDD patients showed decreased GMD in the right medial and left lateral orbitofrontal cortex, right dorsolateral prefrontal cortex (DLPFC), bilateral temporal pole, right superior temporal gyrus, bilateral anterior insular cortex, left parahippocampal gyrus, and left cerebellum. In addition, in MDD patients, there was a negative correlation between GMD values of the right DLPFC and the score of the depression rating scale. CONCLUSIONS: Our findings provided additional support for the involvement of limbic-cortical circuits in the pathophysiology of MDD and preliminary evidence that a defect involving the cerebellum may also be implicated.
PURPOSE: To investigate cerebral and cerebellar gray matter abnormalities in patients with first-episode major depressive disorder (MDD). MATERIALS AND METHODS: We examined the structural difference in regional gray matter density (GMD) between 22 first-episode MDDpatients and 30 age-, gender- and education-matched healthy controls by optimized voxel-based morphometry (VBM) based on magnetic resonance imaging. RESULTS: Compared with healthy controls, MDDpatients showed decreased GMD in the right medial and left lateral orbitofrontal cortex, right dorsolateral prefrontal cortex (DLPFC), bilateral temporal pole, right superior temporal gyrus, bilateral anterior insular cortex, left parahippocampal gyrus, and left cerebellum. In addition, in MDDpatients, there was a negative correlation between GMD values of the right DLPFC and the score of the depression rating scale. CONCLUSIONS: Our findings provided additional support for the involvement of limbic-cortical circuits in the pathophysiology of MDD and preliminary evidence that a defect involving the cerebellum may also be implicated.
Authors: Eva Henje Blom; Colm G Connolly; Tiffany C Ho; Kaja Z LeWinn; Nisreen Mobayed; Laura Han; Martin P Paulus; Jing Wu; Alan N Simmons; Tony T Yang Journal: J Affect Disord Date: 2015-03-14 Impact factor: 4.839
Authors: M Adamaszek; F D'Agata; R Ferrucci; C Habas; S Keulen; K C Kirkby; M Leggio; P Mariën; M Molinari; E Moulton; L Orsi; F Van Overwalle; C Papadelis; A Priori; B Sacchetti; D J Schutter; C Styliadis; J Verhoeven Journal: Cerebellum Date: 2017-04 Impact factor: 3.847
Authors: Simon Newstead; Hayley Young; David Benton; Gabriela Jiga-Boy; Maria L Andrade Sienz; R M Clement; Frédéric Boy Journal: Exp Brain Res Date: 2017-11-02 Impact factor: 1.972
Authors: Cynthia B da Silva; Clarissa L Yasuda; Anelyssa D'Abreu; Fernando Cendes; Iscia Lopes-Cendes; Marcondes C França Journal: Cerebellum Date: 2013-06 Impact factor: 3.847