Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.

Literature DB >> 20462759

Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.

Guangrong Zheng¹, Zhenfa Zhang, Paul R Lockman, Werner J Geldenhuys, David D Allen, Linda P Dwoskin, Peter A Crooks.

Abstract

A series of bis-azaaromatic quaternary ammonium compounds containing flexible polymethylenic linkers as well as conformationally restricted linkers were evaluated for their affinity for the blood-brain barrier choline transporter (BBB-ChT). The preliminary structure-activity relationships obtained from this study suggest that incorporating a linear, conformationally restricted linker into the molecule improves affinity for the BBB-ChT. Copyright 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20462759 PMCID： PMC3725989 DOI： 10.1016/j.bmcl.2010.04.098

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

25 in total

1. Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter.

Authors: Werner J Geldenhuys; Paul R Lockman; James H McAfee; Kevin T Fitzpatrick; Cornelis J Van der Schyf; David D Allen
Journal: Bioorg Med Chem Lett Date: 2004-06-21 Impact factor: 2.823

2. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.

Authors: Peter A Crooks; Joshua T Ayers; Rui Xu; Sangeetha P Sumithran; Vladimir P Grinevich; Lincoln H Wilkins; A Gabriela Deaciuc; David D Allen; Linda P Dwoskin
Journal: Bioorg Med Chem Lett Date: 2004-04-19 Impact factor: 2.823

3. An in situ brain perfusion technique to study cerebrovascular transport in the rat.

Authors: Y Takasato; S I Rapoport; Q R Smith
Journal: Am J Physiol Date: 1984-09

4. Cation transport specificity at the blood-brain barrier.

Authors: Paul R Lockman; James H McAfee; Werner J Geldenhuys; David D Allen
Journal: Neurochem Res Date: 2004-12 Impact factor: 3.996

5. Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.

Authors: N M Neugebauer; Z Zhang; P A Crooks; L P Dwoskin; M T Bardo
Journal: Psychopharmacology (Berl) Date: 2005-10-12 Impact factor: 4.530

6. 3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.

Authors: Werner J Geldenhuys; Paul R Lockman; Tiffany H Nguyen; Cornelis J Van der Schyf; Peter A Crooks; Linda P Dwoskin; David D Allen
Journal: Bioorg Med Chem Date: 2005-07-01 Impact factor: 3.641

7. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.

Authors: David D Allen; Paul R Lockman; Karen E Roder; Linda P Dwoskin; Peter A Crooks
Journal: J Pharmacol Exp Ther Date: 2003-03 Impact factor: 4.030

Review 8. The transport of choline.

Authors: P R Lockman; D D Allen
Journal: Drug Dev Ind Pharm Date: 2002-08 Impact factor: 3.225

4. In silico predictive model to determine vector-mediated transport properties for the blood-brain barrier choline transporter.

Authors: Sergey Shityakov; Carola Förster
Journal: Adv Appl Bioinform Chem Date: 2014-09-02

5. The yjdF riboswitch candidate regulates gene expression by binding diverse azaaromatic compounds.

Authors: Sanshu Li; Xue Ying Hwang; Shira Stav; Ronald R Breaker
Journal: RNA Date: 2016-02-03 Impact factor: 4.942

5 in total

Bis-azaaromatic quaternary ammonium salts as ligands for the blood-brain barrier choline transporter.

1. Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter.

2. Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.

3. An in situ brain perfusion technique to study cerebrovascular transport in the rat.

4. Cation transport specificity at the blood-brain barrier.

5. Effect of a novel nicotinic receptor antagonist, N,N'-dodecane-1,12-diyl-bis-3-picolinium dibromide, on nicotine self-administration and hyperactivity in rats.

6. 3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter.

7. Active transport of high-affinity choline and nicotine analogs into the central nervous system by the blood-brain barrier choline transporter.

Review 8. The transport of choline.

Review 9. Drug and gene targeting to the brain with molecular Trojan horses.

Review 10. The blood-brain barrier choline transporter as a brain drug delivery vector.

Review 1. Transendothelial Transport and Its Role in Therapeutics.

Review 2. Nicotinic receptor antagonists as treatments for nicotine abuse.

Review 3. Molecular determinants of blood-brain barrier permeation.

4. In silico predictive model to determine vector-mediated transport properties for the blood-brain barrier choline transporter.

5. The yjdF riboswitch candidate regulates gene expression by binding diverse azaaromatic compounds.