Literature DB >> 15050618

Development of subtype-selective ligands as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.

Peter A Crooks1, Joshua T Ayers, Rui Xu, Sangeetha P Sumithran, Vladimir P Grinevich, Lincoln H Wilkins, A Gabriela Deaciuc, David D Allen, Linda P Dwoskin.   

Abstract

N-n-Alkylation of nicotine converts it from an agonist into an antagonist at neuronal nicotinic acetylcholine receptor subtypes mediating nicotine-evoked dopamine release. Conformationally restricted analogues exhibit both high affinity and selectivity at this site, and are able to access the brain due to their ability to act as substrates for the blood-brain barrier choline transporter.

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Year:  2004        PMID： 15050618     DOI： 10.1016/j.bmcl.2003.10.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  19 in total

1.  Natural product-derived quaternary ammonium compounds with potent antimicrobial activity.

Authors:  Maureen D Joyce; Megan C Jennings; Celina N Santiago; Madison H Fletcher; William M Wuest; Kevin Pc Minbiole
Journal:  J Antibiot (Tokyo)       Date:  2015-11-18       Impact factor: 2.649

2.  First-principles calculation of pKa for cocaine, nicotine, neurotransmitters, and anilines in aqueous solution.

Authors:  Haiting Lu; Xi Chen; Chang-Guo Zhan
Journal:  J Phys Chem B       Date:  2007-08-11       Impact factor: 2.991

3.  Discovery of a novel nicotinic receptor antagonist for the treatment of nicotine addiction: 1-(3-Picolinium)-12-triethylammonium-dodecane dibromide (TMPD).

Authors:  Linda P Dwoskin; B Matthew Joyce; Guangrong Zheng; Nichole M Neugebauer; Vamshi K Manda; Paul Lockman; Roger L Papke; Michael T Bardo; Peter A Crooks
Journal:  Biochem Pharmacol       Date:  2007-07-21       Impact factor: 5.858

4.  Extending the analysis of nicotinic receptor antagonists with the study of alpha6 nicotinic receptor subunit chimeras.

Authors:  Roger L Papke; Linda P Dwoskin; Peter A Crooks; Guangrong Zheng; Zhenfa Zhang; J Michael McIntosh; Clare Stokes
Journal:  Neuropharmacology       Date:  2008-03-28       Impact factor: 5.250

5.  Modeling multiple species of nicotine and deschloroepibatidine interacting with alpha4beta2 nicotinic acetylcholine receptor: from microscopic binding to phenomenological binding affinity.

Authors:  Xiaoqin Huang; Fang Zheng; Peter A Crooks; Linda P Dwoskin; Chang-Guo Zhan
Journal:  J Am Chem Soc       Date:  2005-10-19       Impact factor: 15.419

6.  Tetrakis-azaaromatic quaternary ammonium salts: novel subtype-selective antagonists at neuronal nicotinic receptors that mediate nicotine-evoked dopamine release.

Authors:  Zhenfa Zhang; Guangrong Zheng; Marharyta Pivavarchyk; A Gabriela Deaciuc; Linda P Dwoskin; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2008-09-26       Impact factor: 2.823

7.  Scientific overview: 2013 BBC plenary symposium on tobacco addiction.

Authors:  M De Biasi; I McLaughlin; E E Perez; P A Crooks; L P Dwoskin; M T Bardo; P R Pentel; D Hatsukami
Journal:  Drug Alcohol Depend       Date:  2014-06-02       Impact factor: 4.492

8.  Predictive screening model for potential vector-mediated transport of cationic substrates at the blood-brain barrier choline transporter.

Authors:  Werner J Geldenhuys; Vamshi K Manda; Rajendar K Mittapalli; Cornelis J Van der Schyf; Peter A Crooks; Linda P Dwoskin; David D Allen; Paul R Lockman
Journal:  Bioorg Med Chem Lett       Date:  2009-12-28       Impact factor: 2.823

9.  Computational neural network analysis of the affinity of N-n-alkylnicotinium salts for the alpha4beta2* nicotinic acetylcholine receptor.

Authors:  Fang Zheng; Guangrong Zheng; A Gabriela Deaciuc; Chang-Guo Zhan; Linda P Dwoskin; Peter A Crooks
Journal:  J Enzyme Inhib Med Chem       Date:  2009-02       Impact factor: 5.051

10.  Tris-azaaromatic quaternary ammonium salts: Novel templates as antagonists at nicotinic receptors mediating nicotine-evoked dopamine release.

Authors:  Guangrong Zheng; Sangeetha P Sumithran; Agripina G Deaciuc; Linda P Dwoskin; Peter A Crooks
Journal:  Bioorg Med Chem Lett       Date:  2007-10-22       Impact factor: 2.823
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