Literature DB >> 20461252

Feasibility of in vivo 15N MRS detection of hyperpolarized 15N labeled choline in rats.

Cristina Cudalbu1, Arnaud Comment, Fiodar Kurdzesau, Ruud B van Heeswijk, Kai Uffmann, Sami Jannin, Vladimir Denisov, Deniz Kirik, Rolf Gruetter.   

Abstract

The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo(13)C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized (15)N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 +/- 16 s) and in vivo (126 +/- 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized (15)N labeled choline in live animals.

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Year:  2010        PMID： 20461252     DOI： 10.1039/c002309b

Source DB:  PubMed          Journal:  Phys Chem Chem Phys        ISSN： 1463-9076            Impact factor:   3.676


  46 in total

1.  Hyperpolarizing Concentrated Metronidazole 15 NO2 Group over Six Chemical Bonds with More than 15 % Polarization and a 20 Minute Lifetime.

Authors:  Roman V Shchepin; Jonathan R Birchall; Nikita V Chukanov; Kirill V Kovtunov; Igor V Koptyug; Thomas Theis; Warren S Warren; Juri G Gelovani; Boyd M Goodson; Sepideh Shokouhi; Matthew S Rosen; Yi-Fen Yen; Wellington Pham; Eduard Y Chekmenev
Journal:  Chemistry       Date:  2019-05-30       Impact factor: 5.236

2.  Toward hyperpolarized molecular imaging of HIV: synthesis and longitudinal relaxation properties of (15) N-Azidothymidine.

Authors:  Roman V Shchepin; Eduard Y Chekmenev
Journal:  J Labelled Comp Radiopharm       Date:  2014-08-25       Impact factor: 1.921

3.  A versatile synthetic route to the preparation of 15 N heterocycles.

Authors:  Nikita V Chukanov; Bryce E Kidd; Larisa M Kovtunova; Valerii I Bukhtiyarov; Roman V Shchepin; Eduard Y Chekmenev; Boyd M Goodson; Kirill V Kovtunov; Igor V Koptyug
Journal:  J Labelled Comp Radiopharm       Date:  2019-01-07       Impact factor: 1.921

Review 4.  Metabolic effects of signal transduction inhibition in cancer assessed by magnetic resonance spectroscopy.

Authors:  Siver Andreas Moestue; Olav Engebraaten; Ingrid Susann Gribbestad
Journal:  Mol Oncol       Date:  2011-04-23       Impact factor: 6.603

Review 5.  13C MRS studies of neuroenergetics and neurotransmitter cycling in humans.

Authors:  Douglas L Rothman; Henk M De Feyter; Robin A de Graaf; Graeme F Mason; Kevin L Behar
Journal:  NMR Biomed       Date:  2011-08-31       Impact factor: 4.044

Review 6.  Metabolic and Molecular Imaging with Hyperpolarised Tracers.

Authors:  Jason Graham Skinner; Luca Menichetti; Alessandra Flori; Anna Dost; Andreas Benjamin Schmidt; Markus Plaumann; Ferdia Aiden Gallagher; Jan-Bernd Hövener
Journal:  Mol Imaging Biol       Date:  2018-12       Impact factor: 3.488

7.  Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange.

Authors:  Johannes F P Colell; Meike Emondts; Angus W J Logan; Kun Shen; Junu Bae; Roman V Shchepin; Gerardo X Ortiz; Peter Spannring; Qiu Wang; Steven J Malcolmson; Eduard Y Chekmenev; Martin C Feiters; Floris P J T Rutjes; Bernhard Blümich; Thomas Theis; Warren S Warren
Journal:  J Am Chem Soc       Date:  2017-05-30       Impact factor: 15.419

8.  Imaging of Biomolecular NMR Signals Amplified by Reversible Exchange with Parahydrogen Inside an MRI Scanner.

Authors:  Kirill V Kovtunov; Bryce E Kidd; Oleg G Salnikov; Liana B Bales; Max E Gemeinhardt; Jonathan Gesiorski; Roman V Shchepin; Eduard Y Chekmenev; Boyd M Goodson; Igor V Koptyug
Journal:  J Phys Chem C Nanomater Interfaces       Date:  2017-11-01       Impact factor: 4.126

9.  Dephosphorylation and biodistribution of 1-¹³C-phospholactate in vivo.

Authors:  Roman V Shchepin; Wellington Pham; Eduard Y Chekmenev
Journal:  J Labelled Comp Radiopharm       Date:  2014-07-03       Impact factor: 1.921

10.  Current and emerging quantitative magnetic resonance imaging methods for assessing and predicting the response of breast cancer to neoadjuvant therapy.

Authors:  Richard G Abramson; Lori R Arlinghaus; Jared A Weis; Xia Li; Adrienne N Dula; Eduard Y Chekmenev; Seth A Smith; Michael I Miga; Vandana G Abramson; Thomas E Yankeelov
Journal:  Breast Cancer (Dove Med Press)       Date:  2012-10
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