| Literature DB >> 28443329 |
Johannes F P Colell1, Meike Emondts2, Angus W J Logan1, Kun Shen1, Junu Bae1, Roman V Shchepin3, Gerardo X Ortiz1, Peter Spannring4, Qiu Wang1, Steven J Malcolmson1, Eduard Y Chekmenev3,5, Martin C Feiters4, Floris P J T Rutjes4, Bernhard Blümich2, Thomas Theis1, Warren S Warren1,6.
Abstract
Signal amplification by reversible exchange (SABRE) is an inexpensive, fast, and even continuous hyperpolarization technique that uses para-hydrogen as hyperpolarization source. However, current SABRE faces a number of stumbling blocks for translation to biochemical and clinical settings. Difficulties include inefficient polarization in water, relatively short-lived 1H-polarization, and relatively limited substrate scope. Here we use a water-soluble polarization transfer catalyst to hyperpolarize nitrogen-15 in a variety of molecules with SABRE-SHEATH (SABRE in shield enables alignment transfer to heteronuclei). This strategy works in pure H2O or D2O solutions, on substrates that could not be hyperpolarized in traditional 1H-SABRE experiments, and we record 15N T1 relaxation times of up to 2 min.Entities:
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Year: 2017 PMID： 28443329 PMCID： PMC5578426 DOI： 10.1021/jacs.7b00569
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419