| Literature DB >> 20457608 |
Daniel M Jones1, John McLauchlan.
Abstract
Hepatitis C virus is a blood-borne virus that typically establishes a chronic infection in the liver, which often results in cirrhosis and hepatocellular carcinoma. Progress in understanding the complete virus life cycle has been greatly enhanced by the recent availability of a tissue culture system that produces infectious virus progeny. Thus, it is now possible to gain insight into the roles played by viral components in assembly and egress and the cellular pathways that contribute to virion formation. This minireview describes the key determining viral and host factors that are needed to produce infectious virus.Entities:
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Year: 2010 PMID: 20457608 PMCID: PMC2906262 DOI: 10.1074/jbc.R110.133017
Source DB: PubMed Journal: J Biol Chem ISSN: 0021-9258 Impact factor: 5.157