| Literature DB >> 20453868 |
Dale J Langford1, Andrea L Bailey, Mona Lisa Chanda, Sarah E Clarke, Tanya E Drummond, Stephanie Echols, Sarah Glick, Joelle Ingrao, Tammy Klassen-Ross, Michael L Lacroix-Fralish, Lynn Matsumiya, Robert E Sorge, Susana G Sotocinal, John M Tabaka, David Wong, Arn M J M van den Maagdenberg, Michel D Ferrari, Kenneth D Craig, Jeffrey S Mogil.
Abstract
Facial expression is widely used as a measure of pain in infants; whether nonhuman animals display such pain expressions has never been systematically assessed. We developed the mouse grimace scale (MGS), a standardized behavioral coding system with high accuracy and reliability; assays involving noxious stimuli of moderate duration are accompanied by facial expressions of pain. This measure of spontaneously emitted pain may provide insight into the subjective pain experience of mice.Entities:
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Year: 2010 PMID: 20453868 DOI: 10.1038/nmeth.1455
Source DB: PubMed Journal: Nat Methods ISSN: 1548-7091 Impact factor: 28.547