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Literature DB >> 20452813

The chemical biology of new drugs in the development for tuberculosis.

Abstract

With the worldwide emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (Mtb), there are serious concerns about the continued ability to contain this disease. We discuss the most promising new drugs in late-stage development that might be useful in treating MDR and XDR forms of the disease. These agents have novel mechanisms of action that are not targeted by the standard drugs used presently to treat susceptible strains. 2010 Elsevier Ltd. All rights reserved.

Entities: Chemical Disease Mutation Species

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Year: 2010 PMID： 20452813 PMCID： PMC2918717 DOI： 10.1016/j.cbpa.2010.04.008

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

91 in total

1. Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.

Authors: Feng Wang; Craig Cassidy; James C Sacchettini
Journal: Antimicrob Agents Chemother Date: 2006-08 Impact factor: 5.191

Review 2. The chemotherapy of pulmonary tuberculosis: a review.

Authors: W Fox
Journal: Chest Date: 1979-12 Impact factor: 9.410

3. Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines.

Authors: Marina Protopopova; Colleen Hanrahan; Boris Nikonenko; Rowena Samala; Ping Chen; Jackie Gearhart; Leo Einck; Carol A Nacy
Journal: J Antimicrob Chemother Date: 2005-09-19 Impact factor: 5.790

4. Bactericidal activities of R207910 and other newer antimicrobial agents against Mycobacterium leprae in mice.

Authors: Baohong Ji; Aurélie Chauffour; Koen Andries; Vincent Jarlier
Journal: Antimicrob Agents Chemother Date: 2006-04 Impact factor: 5.191

5. The arabinosyltransferase EmbC is inhibited by ethambutol in Mycobacterium tuberculosis.

Authors: R Goude; A G Amin; D Chatterjee; T Parish
Journal: Antimicrob Agents Chemother Date: 2009-07-13 Impact factor: 5.191

6. Recombinant expression and characterization of the major beta-lactamase of Mycobacterium tuberculosis.

Authors: R K Voladri; D L Lakey; S H Hennigan; B E Menzies; K M Edwards; D S Kernodle
Journal: Antimicrob Agents Chemother Date: 1998-06 Impact factor: 5.191

Review 7. Linezolid: a review of safety and tolerability.

Authors: Donald C Vinh; Ethan Rubinstein
Journal: J Infect Date: 2009-09 Impact factor: 6.072

8. Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.

Authors: Lee W Tremblay; Jean-Emmanuel Hugonnet; John S Blanchard
Journal: Biochemistry Date: 2008-04-19 Impact factor: 3.162

Review 9. Role of reactive oxygen species in antibiotic action and resistance.

Authors: Daniel J Dwyer; Michael A Kohanski; James J Collins
Journal: Curr Opin Microbiol Date: 2009-07-31 Impact factor: 7.934

10. PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.

Authors: Ramandeep Singh; Ujjini Manjunatha; Helena I M Boshoff; Young Hwan Ha; Pornwaratt Niyomrattanakit; Richard Ledwidge; Cynthia S Dowd; Ill Young Lee; Pilho Kim; Liang Zhang; Sunhee Kang; Thomas H Keller; Jan Jiricek; Clifton E Barry
Journal: Science Date: 2008-11-28 Impact factor: 63.714

18 in total

1. Impact of Fgd1 and ddn diversity in Mycobacterium tuberculosis complex on in vitro susceptibility to PA-824.

Authors: Silke Feuerriegel; Claudio U Köser; Davide Baù; Sabine Rüsch-Gerdes; David K Summers; John A C Archer; Marc A Marti-Renom; Stefan Niemann
Journal: Antimicrob Agents Chemother Date: 2011-09-19 Impact factor: 5.191

Review 2. Adenylating enzymes in Mycobacterium tuberculosis as drug targets.

Authors: Benjamin P Duckworth; Kathryn M Nelson; Courtney C Aldrich
Journal: Curr Top Med Chem Date: 2012 Impact factor: 3.295

3. Potent inhibitors of a shikimate pathway enzyme from Mycobacterium tuberculosis: combining mechanism- and modeling-based design.

Authors: Sebastian Reichau; Wanting Jiao; Scott R Walker; Richard D Hutton; Edward N Baker; Emily J Parker
Journal: J Biol Chem Date: 2011-03-15 Impact factor: 5.157

4. Mechanism-based inactivation by aromatization of the transaminase BioA involved in biotin biosynthesis in Mycobaterium tuberculosis.

Authors: Ce Shi; Todd W Geders; Sae Woong Park; Daniel J Wilson; Helena I Boshoff; Orishadipe Abayomi; Clifton E Barry; Dirk Schnappinger; Barry C Finzel; Courtney C Aldrich
Journal: J Am Chem Soc Date: 2011-10-24 Impact factor: 15.419

5. Bis-spirochromanones as potent inhibitors of Mycobacterium tuberculosis: synthesis and biological evaluation.

Authors: Ashok Dongamanti; Vikas Kumar Aamate; Mohan Gandhi Devulapally; Srinivas Gundu; Saikrishna Balabadra; Vijjulatha Manga; Perumal Yogeeswari; Dharmarajan Sriram; Sridhar Balasubramanian
Journal: Mol Divers Date: 2017-08-24 Impact factor: 2.943

6. An isoniazid analogue promotes Mycobacterium tuberculosis-nanoparticle interactions and enhances bacterial killing by macrophages.

Authors: Tatiany J de Faria; Mariane Roman; Nicole M de Souza; Rodrigo De Vecchi; João Vitor de Assis; Ana Lúcia Gomes dos Santos; Ivan H Bechtold; Nathalie Winter; Maurilio José Soares; Luciano Paulino Silva; Mauro V De Almeida; André Báfica
Journal: Antimicrob Agents Chemother Date: 2012-02-13 Impact factor: 5.191

7. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis.

Authors: Kapil Tahlan; Regina Wilson; David B Kastrinsky; Kriti Arora; Vinod Nair; Elizabeth Fischer; S Whitney Barnes; John R Walker; David Alland; Clifton E Barry; Helena I Boshoff
Journal: Antimicrob Agents Chemother Date: 2012-01-17 Impact factor: 5.191