Literature DB >> 16569884

Bactericidal activities of R207910 and other newer antimicrobial agents against Mycobacterium leprae in mice.

Baohong Ji1, Aurélie Chauffour, Koen Andries, Vincent Jarlier.   

Abstract

As measured by a proportional bactericidal technique in the mouse footpad system, the bactericidal activity against Mycobacterium leprae of R207910 was equal to that of rifapentine, rifampin, or moxifloxacin and significantly greater than those of minocycline, PA-824, and linezolid. These data suggest that R207910 may play an important role in treatment of leprosy.

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Year:  2006        PMID： 16569884      PMCID： PMC1426933          DOI： 10.1128/AAC.50.4.1558-1560.2006

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  The effect of ultraviolet light radiation on Mycobacterium leprae.

Authors:  R W Truman; T P Gillis
Journal:  Int J Lepr Other Mycobact Dis       Date:  2000-03

2.  A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis.

Authors:  Koen Andries; Peter Verhasselt; Jerome Guillemont; Hinrich W H Göhlmann; Jean-Marc Neefs; Hans Winkler; Jef Van Gestel; Philip Timmerman; Min Zhu; Ennis Lee; Peter Williams; Didier de Chaffoy; Emma Huitric; Sven Hoffner; Emmanuelle Cambau; Chantal Truffot-Pernot; Nacer Lounis; Vincent Jarlier
Journal:  Science       Date:  2004-12-09       Impact factor: 47.728

3.  Bactericidal activity of a single-dose combination of ofloxacin plus minocycline, with or without rifampin, against Mycobacterium leprae in mice and in lepromatous patients.

Authors:  B Ji; S Sow; E Perani; C Lienhardt; V Diderot; J Grosset
Journal:  Antimicrob Agents Chemother       Date:  1998-05       Impact factor: 5.191

4.  Bactericidal activity of single dose of clarithromycin plus minocycline, with or without ofloxacin, against Mycobacterium leprae in patients.

Authors:  B Ji; P Jamet; E G Perani; S Sow; C Lienhardt; C Petinon; J H Grosset
Journal:  Antimicrob Agents Chemother       Date:  1996-09       Impact factor: 5.191

5.  The "proportional bactericidal test": a method for assessing bactericidal activity in drugs against Mycobacterium leprae in mice.

Authors:  M J Colston; G R Hilson; D K Banerjee
Journal:  Lepr Rev       Date:  1978-03       Impact factor: 0.537

6.  Chemotherapy of leprosy for control programmes.

Authors: 
Journal:  World Health Organ Tech Rep Ser       Date:  1982

7.  Statistical analysis of results obtained by two methods for testing drug activity against Mycobacterium leprae.

Authors:  C C Shepard
Journal:  Int J Lepr Other Mycobact Dis       Date:  1982-03

8.  Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models.

Authors:  Anne J Lenaerts; Veronica Gruppo; Karen S Marietta; Christine M Johnson; Diane K Driscoll; Nicholas M Tompkins; Jerry D Rose; Robert C Reynolds; Ian M Orme
Journal:  Antimicrob Agents Chemother       Date:  2005-06       Impact factor: 5.191

9.  Bactericidal activities of combinations of new drugs against Mycobacterium leprae in nude mice.

Authors:  B Ji; E G Perani; C Petinom; J H Grosset
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

10.  THE EXPERIMENTAL DISEASE THAT FOLLOWS THE INJECTION OF HUMAN LEPROSY BACILLI INTO FOOT-PADS OF MICE.

Authors:  C C Shepard
Journal:  J Exp Med       Date:  1960-09-01       Impact factor: 14.307
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  18 in total

Review 1.  The chemical biology of new drugs in the development for tuberculosis.

Authors:  Clifton E Barry; John S Blanchard
Journal:  Curr Opin Chem Biol       Date:  2010-05-07       Impact factor: 8.822

2.  In vitro and in vivo activities of rifampin, streptomycin, amikacin, moxifloxacin, R207910, linezolid, and PA-824 against Mycobacterium ulcerans.

Authors:  Baohong Ji; Sébastien Lefrançois; Jerome Robert; Aurélie Chauffour; Chantal Truffot; Vincent Jarlier
Journal:  Antimicrob Agents Chemother       Date:  2006-06       Impact factor: 5.191

Review 3.  New antituberculous drugs derived from natural products: current perspectives and issues in antituberculous drug development.

Authors:  Masayuki Igarashi; Yoshimasa Ishizaki; Yoshiaki Takahashi
Journal:  J Antibiot (Tokyo)       Date:  2017-11-01       Impact factor: 2.649

4.  An enlarged, adaptable active site in CYP164 family P450 enzymes, the sole P450 in Mycobacterium leprae.

Authors:  Christopher R J Agnew; Andrew G S Warrilow; Nicholas M Burton; David C Lamb; Steven L Kelly; R Leo Brady
Journal:  Antimicrob Agents Chemother       Date:  2011-10-28       Impact factor: 5.191

Review 5.  Bedaquiline for the treatment of multidrug-resistant tuberculosis: great promise or disappointment?

Authors:  Stephen K Field
Journal:  Ther Adv Chronic Dis       Date:  2015-07       Impact factor: 5.091

6.  Combinations of R207910 with drugs used to treat multidrug-resistant tuberculosis have the potential to shorten treatment duration.

Authors:  Nacer Lounis; Nicolas Veziris; Aurélie Chauffour; Chantal Truffot-Pernot; Koen Andries; Vincent Jarlier
Journal:  Antimicrob Agents Chemother       Date:  2006-09-05       Impact factor: 5.191

7.  Mycobacterium leprae is naturally resistant to PA-824.

Authors:  Ujjini H Manjunatha; Ramanuj Lahiri; Baljit Randhawa; Cynthia S Dowd; James L Krahenbuhl; Clifton E Barry
Journal:  Antimicrob Agents Chemother       Date:  2006-10       Impact factor: 5.191

8.  The diarylquinoline R207910 is bactericidal against Mycobacterium leprae in mice at low dose and administered intermittently.

Authors:  Robert Gelber; Koen Andries; Rose Maria D Paredes; Cora Evelyn S Andaya; Jasmin Burgos
Journal:  Antimicrob Agents Chemother       Date:  2009-07-13       Impact factor: 5.191

9.  Antigen-specific cellular and humoral responses are induced by intradermal Mycobacterium leprae infection of the mouse ear.

Authors:  Malcolm S Duthie; Stephen T Reece; Ramanuj Lahiri; Wakako Goto; Vanitha S Raman; Juliette Kaplan; Greg C Ireton; Sylvie Bertholet; Thomas P Gillis; James L Krahenbuhl; Steven G Reed
Journal:  Infect Immun       Date:  2007-08-27       Impact factor: 3.441

10.  Impact of the interaction of R207910 with rifampin on the treatment of tuberculosis studied in the mouse model.

Authors:  Nacer Lounis; Tom Gevers; Joke Van Den Berg; Koen Andries
Journal:  Antimicrob Agents Chemother       Date:  2008-07-21       Impact factor: 5.191
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