Literature DB >> 20452706

Discovery of new 1,3,5-triazine scaffolds with potent activity against Mycobacterium tuberculosis H37Rv.

Naresh Sunduru1, Leena Gupta, Vinita Chaturvedi, Richa Dwivedi, Sudhir Sinha, Prem M S Chauhan.   

Abstract

A series of eighty one 2,4,6-trisubstituted-1,3,5-triazines were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Fifteen compounds from this series exhibited good to moderate activity with an MIC in the range 1.56-3.12 microg/mL and most of them were found to be nontoxic against VERO cells and MBMDMQs (mouse bone marrow derived macrophages). This is for the first time that 2,4,6-trisubstituted-1,3,5-triazines were identified as a potent inhibitors of M. tuberculosis H37Rv. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20452706     DOI： 10.1016/j.ejmech.2010.04.017

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  6 in total

Review 1.  Transition metal-free one-pot synthesis of nitrogen-containing heterocycles.

Authors:  Simpal Kumari; Dharma Kishore; Sarvesh Paliwal; Rajani Chauhan; Jaya Dwivedi; Aakanksha Mishra
Journal:  Mol Divers       Date:  2015-06-09       Impact factor: 2.943

2.  Facile Synthesis, Characterization, and In Vitro Antimicrobial Screening of a New Series of 2,4,6-Trisubstituted-s-triazine Based Compounds.

Authors:  Ravi Bhushan Singh; Nirupam Das; Md Kamaruz Zaman
Journal:  Int J Med Chem       Date:  2015-01-31

3.  Exploring the Orthogonal Chemoselectivity of 2,4,6-Trichloro-1,3,5-Triazine (TCT) as a Trifunctional Linker With Different Nucleophiles: Rules of the Game.

Authors:  Anamika Sharma; Ayman El-Faham; Beatriz G de la Torre; Fernando Albericio
Journal:  Front Chem       Date:  2018-11-01       Impact factor: 5.221

4.  Design and Synthesis of Aza-/Oxa Heterocycle-Based Conjugates as Novel Anti-Inflammatory Agents Targeting Cyclooxygenase-2.

Authors:  Sukhmeet Kaur; Priya Kumari; Gurjit Singh; Rajbir Bhatti; Palwinder Singh
Journal:  ACS Omega       Date:  2018-05-30

5.  The Antiproliferative and Apoptotic Effect of a Novel Synthesized S-Triazine Dipeptide Series, and Toxicity Screening in Zebrafish Embryos.

Authors:  Azizah M Malebari; Rakia Abd Alhameed; Zainab Almarhoon; Muhammad Farooq; Mohammad A M Wadaan; Anamika Sharma; Beatriz G de la Torre; Fernando Albericio; Ayman El-Faham
Journal:  Molecules       Date:  2021-02-22       Impact factor: 4.411

6.  Synthesis, SAR and antibacterial activity of hybrid chloro, dichloro-phenylthiazolyl-s-triazines.

Authors:  Prashant Gahtori; Surajit Kumar Ghosh; Brijesh Singh; Udaya Pratap Singh; Hans Raj Bhat; Archana Uppal
Journal:  Saudi Pharm J       Date:  2011-05-17       Impact factor: 4.330
  6 in total

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