Literature DB >> 20452613

Upper gastrointestinal carcinogenesis: H. pylori and stem cell cross-talk.

Ioannis Pilpilidis1, Jannis Kountouras, Christos Zavos, Panagiotis Katsinelos.   

Abstract

Chronic inflammation of the gastric epithelium has been associated with the pathogenesis of gastric cancer, as it was postulated by Corea's model of gastric carcinogenesis. Helicobacter pylori (Hp) regulates this inflammatory process and promotes gastric carcinogenesis through induction of gene mutations and protein modulation. Recent data raise the cancer stem cell hypothesis, which implies a central role of multipotent cancer cells in oncogenesis of various solid tumors. This review provides a synopsis of gastric cancer initiation and promotion through Hp and stem cell signaling pathways. The expanding research field of Hp-related cancer stem cell biology may offer novel implications for future treatment of upper gastrointestinal cancer.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20452613     DOI： 10.1016/j.jss.2010.02.012

Source DB:  PubMed          Journal:  J Surg Res        ISSN： 0022-4804            Impact factor:   2.192


  14 in total

1.  Helicobacter pylori infection and gastrointestinal tract cancer biology: considering a double-edged sword reflection.

Authors:  Jannis Kountouras; Michael Doulberis; Apostolis Papaefthymiou; Stergios A Polyzos; Maria Touloumtzi; Vardaka Elisabeth; Nikolaos Kapetanakis; Christos Liatsos; Emmanouel Gavalas; Panagiotis Katsinelos
Journal:  Cell Mol Life Sci       Date:  2019-04-20       Impact factor: 9.261

2.  Helicobacter pylori infection and colorectal carcinoma: pathologic aspects.

Authors:  Nikolaos Kapetanakis; Jannis Kountouras; Christos Zavos; Stergios A Polyzos; George Kouklakis; Ioannis Venizelos; Christina Nikolaidou; Elizabeth Vardaka; Dimitrios Paikos; Panagiotis Katsinelos; Iordanis Romiopoulos
Journal:  J Gastrointest Oncol       Date:  2012-12

3.  Intestine-specific homeobox (ISX) induces intestinal metaplasia and cell proliferation to contribute to gastric carcinogenesis.

Authors:  Soichiro Sue; Wataru Shibata; Eri Kameta; Takeshi Sato; Yasuaki Ishii; Hiroaki Kaneko; Haruo Miwa; Tomohiko Sasaki; Toshihide Tamura; Masaaki Kondo; Shin Maeda
Journal:  J Gastroenterol       Date:  2016-02-12       Impact factor: 7.527

4.  Cancer stem cells in Helicobacter pylori infection and aging: Implications for gastric carcinogenesis.

Authors:  Edi Levi; Paula Sochacki; Nabiha Khoury; Bhaumik B Patel; Adhip Pn Majumdar
Journal:  World J Gastrointest Pathophysiol       Date:  2014-08-15

Review 5.  Gastric cancer stem cells: a novel therapeutic target.

Authors:  Shree Ram Singh
Journal:  Cancer Lett       Date:  2013-04-10       Impact factor: 8.679

6.  Correlation between Helicobacter pylori-associated gastric diseases and colorectal neoplasia.

Authors:  Ying Qing; Min Wang; Ying-Min Lin; Dong Wu; Jing-Yu Zhu; Lang Gao; Yan-Yan Liu; Teng-Fei Yin
Journal:  World J Gastroenterol       Date:  2016-05-14       Impact factor: 5.742

7.  Cancer Stem Cell Markers CD44, CD133 in Primary Gastric Adenocarcinoma.

Authors:  Anahita Nosrati; Farshad Naghshvar; Somaieh Khanari
Journal:  Int J Mol Cell Med       Date:  2014

8.  Bone Marrow-Derived Stem Cells in Pathogenesis of Helicobacter pylori-Associated Gastrointestinal Cancer.

Authors:  Jannis Kountouras; Stergios A Polyzos; Christos Zavos; Nikolaos Kapetanakis; Ioannis Pilpilidis; Michael Vrettos; Constantinos Kountouras; Elizabeth Vardaka; Christos Zeglinas; Panagiotis Katsinelos; Georgia Deretzi
Journal:  Clin Transl Gastroenterol       Date:  2015-12-10       Impact factor: 4.488

9.  Utility of a bacterial infection model to study epithelial-mesenchymal transition, mesenchymal-epithelial transition or tumorigenesis.

Authors:  P Chandrakesan; B Roy; L U M R Jakkula; I Ahmed; P Ramamoorthy; O Tawfik; R Papineni; C Houchen; S Anant; S Umar
Journal:  Oncogene       Date:  2013-06-10       Impact factor: 8.756

10.  Mucin 1 gene (MUC1) and gastric-cancer susceptibility.

Authors:  Norihisa Saeki; Hiromi Sakamoto; Teruhiko Yoshida
Journal:  Int J Mol Sci       Date:  2014-05-07       Impact factor: 5.923
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