Literature DB >> 23583679

Gastric cancer stem cells: a novel therapeutic target.

Shree Ram Singh1.   

Abstract

Gastric cancer remains one of the leading causes of global cancer mortality. Multipotent gastric stem cells have been identified in both mouse and human stomachs, and they play an essential role in the self-renewal and homeostasis of gastric mucosa. There are several environmental and genetic factors known to promote gastric cancer. In recent years, numerous in vitro and in vivo studies suggest that gastric cancer may originate from normal stem cells or bone marrow-derived mesenchymal cells, and that gastric tumors contain cancer stem cells. Cancer stem cells are believed to share a common microenvironment with normal niche, which play an important role in gastric cancer and tumor growth. This mini-review presents a brief overview of the recent developments in gastric cancer stem cell research. The knowledge gained by studying cancer stem cells in gastric mucosa will support the development of novel therapeutic strategies for gastric cancer. Published by Elsevier Ireland Ltd.

Entities:  

Keywords:  Cancer stem cells; Gastric cancer; Gastric epithelial cells; Stem cells; Stomach

Mesh：

Substances：

Year:  2013        PMID： 23583679      PMCID： PMC3755024          DOI： 10.1016/j.canlet.2013.03.035

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  158 in total

1.  Intracellular Helicobacter pylori in gastric epithelial progenitors.

Authors:  Jung D Oh; Sherif M Karam; Jeffrey I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  2005-03-28       Impact factor: 11.205

2.  SOX9 is expressed in normal stomach, intestinal metaplasia, and gastric carcinoma in humans.

Authors:  Miho Sashikawa Kimura; Hiroyuki Mutoh; Kentaro Sugano
Journal:  J Gastroenterol       Date:  2011-08-23       Impact factor: 7.527

3.  Runx3 protects gastric epithelial cells against epithelial-mesenchymal transition-induced cellular plasticity and tumorigenicity.

Authors:  Dominic Chih-Cheng Voon; Huajing Wang; Jason Kin Wai Koo; Tu Anh Pham Nguyen; Yit Teng Hor; Yeh-Shiu Chu; Kosei Ito; Hiroshi Fukamachi; Shing Leng Chan; Jean Paul Thiery; Yoshiaki Ito
Journal:  Stem Cells       Date:  2012-10       Impact factor: 6.277

Review 4.  Regeneration of the gastric mucosa and its glands from stem cells.

Authors:  Werner Hoffmann
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

Review 5.  Understanding the cancer stem cell.

Authors:  S Bomken; K Fiser; O Heidenreich; J Vormoor
Journal:  Br J Cancer       Date:  2010-07-27       Impact factor: 7.640

6.  Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells.

Authors:  Marios Giannakis; Swaine L Chen; Sherif M Karam; Lars Engstrand; Jeffrey I Gordon
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-10       Impact factor: 11.205

7.  Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas.

Authors:  Arnout G Schepers; Hugo J Snippert; Daniel E Stange; Maaike van den Born; Johan H van Es; Marc van de Wetering; Hans Clevers
Journal:  Science       Date:  2012-08-01       Impact factor: 47.728

Review 8.  Cancer stem cells: impact, heterogeneity, and uncertainty.

Authors:  Jeffrey A Magee; Elena Piskounova; Sean J Morrison
Journal:  Cancer Cell       Date:  2012-03-20       Impact factor: 31.743

9.  The spatial distribution of LGR5+ cells correlates with gastric cancer progression.

Authors:  Eva Simon; Diana Petke; Christine Böger; Hans-Michael Behrens; Viktoria Warneke; Matthias Ebert; Christoph Röcken
Journal:  PLoS One       Date:  2012-04-18       Impact factor: 3.240

10.  A restricted cell population propagates glioblastoma growth after chemotherapy.

Authors:  Jian Chen; Yanjiao Li; Tzong-Shiue Yu; Renée M McKay; Dennis K Burns; Steven G Kernie; Luis F Parada
Journal:  Nature       Date:  2012-08-23       Impact factor: 49.962
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  48 in total

Review 1.  Association between cadherin-17 expression and pathological characteristics of gastric cancer: a meta-analysis.

Authors:  Zi-Wen Long; Meng-Long Zhou; Jing-Wei Fu; Xian-Qun Chu; Ya-Nong Wang
Journal:  World J Gastroenterol       Date:  2015-03-28       Impact factor: 5.742

2.  Meta-analysis of the association of glutathione S-transferase T1 null/presence gene polymorphism with the risk of gastric carcinoma.

Authors:  Yuan-Biao Meng; Xiao-Yong Cai; Wen-Qi Lu; Li-Hua Yang; Ting-Qing Gan; Gregor P C Drummen
Journal:  Mol Biol Rep       Date:  2013-12-19       Impact factor: 2.316

3.  RKIP and peroxiredoxin 2 expression predicts the proliferative potential of gastric cancer stem cells.

Authors:  Shao-Feng Yang; Ran Ma; Li-Li Pan; Jing Cao; Nan Sheng
Journal:  Oncol Lett       Date:  2017-12-28       Impact factor: 2.967

4.  HMGA2 regulates CD44 expression to promote gastric cancer cell motility and sphere formation.

Authors:  Junying Sun; Baocun Sun; Dongwang Zhu; Xiulan Zhao; Yanhui Zhang; Xueyi Dong; Na Che; Jing Li; Fang Liu; Nan Zhao; Danfang Zhang; Tieju Liu; Xian Lin
Journal:  Am J Cancer Res       Date:  2017-02-01       Impact factor: 6.166

5.  Distinct biological characterization of the CD44 and CD90 phenotypes of cancer stem cells in gastric cancer cell lines.

Authors:  Xiong Shu; Huiqi Liu; Yunzhi Pan; Lichao Sun; Long Yu; Lixin Sun; Zhihua Yang; Yuliang Ran
Journal:  Mol Cell Biochem       Date:  2019-05-09       Impact factor: 3.396

6.  Expression of NUAK2 in gastric cancer tissue and its effects on the proliferation of gastric cancer cells.

Authors:  Lin Tang; Shu-Juan Tong; Zhen Zhan; Qian Wang; Yuan Tian; Feng Chen
Journal:  Exp Ther Med       Date:  2016-12-19       Impact factor: 2.447

7.  Influence of different hypoxia models on metastatic potential of SGC-7901 gastric cancer cells.

Authors:  Zhi-Feng Miao; Ting-Ting Zhao; Zhen-Ning Wang; Ying-Ying Xu; Xiao-Yun Mao; Jian-Hua Wu; Xing-Yu Liu; Hao Xu; Yi You; Hui-Mian Xu
Journal:  Tumour Biol       Date:  2014-04-12

8.  Gastric Metaplasia Induced by Helicobacter pylori Is Associated with Enhanced SOX9 Expression via Interleukin-1 Signaling.

Authors:  Takako Serizawa; Yoshihiro Hirata; Yoku Hayakawa; Nobumi Suzuki; Kosuke Sakitani; Yohko Hikiba; Sozaburo Ihara; Hiroto Kinoshita; Hayato Nakagawa; Keisuke Tateishi; Kazuhiko Koike
Journal:  Infect Immun       Date:  2015-12-07       Impact factor: 3.441

9.  Transcriptional coexpression network reveals the involvement of varying stem cell features with different dysregulations in different gastric cancer subtypes.

Authors:  Kalaivani Kalamohan; Jayaprakash Periasamy; Divya Bhaskar Rao; Georgina D Barnabas; Srigayatri Ponnaiyan; Kumaresan Ganesan
Journal:  Mol Oncol       Date:  2014-05-09       Impact factor: 6.603

10.  Novel therapy for advanced gastric cancer.

Authors:  Yue Zhang; Shenhong Wu
Journal:  World J Gastrointest Oncol       Date:  2015-11-15
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