Asymmetric hydroamination/cyclization catalyzed by organolanthanide complexes with chiral biaryl-based ligands.

The development of catalysts for intramolecular asymmetric alkene hydroamination has been investigated extensively over the past two decades, since the hydroamination is a highly atom economical process in which an amine N-H bond is added to an unsaturated carbon-carbon bond leading to the formation of nitrogen heterocycles that are building blocks in numerous biologically and pharmacologically active compounds. The organolanthanide catalysts have been shown to be promising in this area. This perspective highlights the recent progress in the development of organolanthanide catalysts with chiral biaryl-backbones for the asymmetric hydroamination/cyclization of non-activated alkenes.