OBJECTIVES: Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction. METHODS:First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferrin iron saturation and ferritin were analyzed, as well as several confounders. HFE C282Y and H63D genotypes were determined. RESULTS: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferrin iron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction. CONCLUSIONS: No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
RCT Entities:
OBJECTIVES: Our objectives were to study the relationship between iron stores, HFE genotypes and the risk for first-ever myocardial infarction. METHODS: First-ever myocardial infarction cases (n=618) and double matched referents from the Northern Sweden Health and Disease Cohort Study were studied in a prospective nested case-referent setting. Plasma iron, total iron binding capacity, transferriniron saturation and ferritin were analyzed, as well as several confounders. HFEC282Y and H63D genotypes were determined. RESULTS: There was an inverse risk association for myocardial infarction in the highest quartiles of iron (OR 0.68; 95% CI 0.48-0.96) and transferriniron saturation (OR 0.62; 95% CI 0.42-0.89) in men. This association, however, was lost after adjusting for C-reactive protein. Women homozygous for H63D had a higher risk for myocardial infarction. CONCLUSIONS: No risk association between high iron stores and first-ever myocardial infarction was found. The higher risk in female H63D homozygotes is probably not related to iron metabolism.
Authors: Asha R Kallianpur; Wanqing Wen; Angelika L Erwin; David B Clifford; Todd Hulgan; Gregory K Robbins Journal: PLoS One Date: 2020-10-15 Impact factor: 3.752