Literature DB >> 20445408

Association between the methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia in Serbian children.

Tatjana Damnjanovic1, Radomir Milicevic, Tanja Novkovic, Olivera Jovicic, Vera Bunjevacki, Biljana Jekic, Ljiljana Lukovic, Ivana Novakovic, Danka Redzic, Jelena Milasin.   

Abstract

SUMMARY: Methylenetetrahydrofolate reductase (MTHFR) regulates the metabolism of folate and methionine, essential components of DNA synthesis and methylation. Polymorphisms in the MTHFR gene have been associated with susceptibility to some types of cancer. We investigated a possible association of MTHFR polymorphisms (677C>T and 1298A>C) and increased risk for acute lymphoblastic leukemia in 78 affected children. The frequencies of both MTHFR 677 genotypes and alleles were significantly different between patients and controls. A significant association between CT/TT individuals and reduced risk of acute lymphoblastic leukemia was found. The odds ratios were 0.53 (95% confidence interval, 032-0.89) and 0.30 (95% confidence interval, 0.12-0.81). Polymorphism 1298 did not show statistical difference between patients and controls.

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Year:  2010        PMID： 20445408     DOI： 10.1097/MPH.0b013e3181cbd252

Source DB:  PubMed          Journal:  J Pediatr Hematol Oncol        ISSN： 1077-4114            Impact factor:   1.289


  8 in total

1.  Gene polymorphisms in the folate metabolic pathway and risk of pediatric acute lymphoblastic leukemia: a case-control study in a Chinese population.

Authors:  Hui Lv; Shao-Yan Hu; Zhi-Zuo Du; Zong Zhai; Lan Cao; Yi-Na Sun; Jun Lu; Jie Li; Hai-Long He; Yi-Huan Chai; Yi Wang
Journal:  Int J Clin Exp Pathol       Date:  2018-03-01

Review 2.  A literature review of MTHFR (C677T and A1298C polymorphisms) and cancer risk.

Authors:  Muzeyyen Izmirli
Journal:  Mol Biol Rep       Date:  2012-10-19       Impact factor: 2.316

3.  The methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and tumor risk: evidence from 134 case-control studies.

Authors:  Min Tang; Shang-Qian Wang; Bian-Jiang Liu; Qiang Cao; Bing-Jie Li; Peng-Chao Li; Yong-Fei Li; Chao Qin; Wei Zhang
Journal:  Mol Biol Rep       Date:  2014-04-18       Impact factor: 2.316

4.  MTHFR gene polymorphism in acute lymphoblastic leukemia among North Indian children: a case-control study and meta-analysis updated from 2011.

Authors:  Nirmalya Roy Moulik; Farah Parveen; Archana Kumar; Shally Awasthi; Suraksha Agrawal
Journal:  J Hum Genet       Date:  2014-06-12       Impact factor: 3.172

5.  The association of methylenetetrahydrofolate reductase genotypes with the risk of childhood leukemia in Taiwan.

Authors:  Jen-Sheng Pei; Chin-Mu Hsu; Chia-Wen Tsai; Wen-Shin Chang; Hong-Xue Ji; Chieh-Lun Hsiao; Chia-En Miao; Yuan-Nian Hsu; Da-Tian Bau
Journal:  PLoS One       Date:  2015-03-20       Impact factor: 3.240

6.  The Frequency of the 677C>T and 1298A>C Polymorphisms in the Methylenetetrahydrofolate Reductase (MTHFR) Gene in the Population.

Authors:  Hilada Nefic; Mirela Mackic-Djurovic; Izet Eminovic
Journal:  Med Arch       Date:  2018-06

7.  Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-analysis including 35 studies.

Authors:  Haigang Wang; Jiali Wang; Lixia Zhao; Xinchun Liu; Wenjie Mi
Journal:  BMC Med Genet       Date:  2012-09-04       Impact factor: 2.103

8.  Association between MTHFR C677T polymorphism and risk of acute lymphoblastic leukemia: a meta-analysis based on 51 case-control studies.

Authors:  Su-yi Li; Jie-yu Ye; En-yu Liang; Li-xia Zhou; Mo Yang
Journal:  Med Sci Monit       Date:  2015-03-12
  8 in total

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