Literature DB >> 20445199

Driving drug discovery: the fundamental role of academic labs.

B Michael Silber1.   

Abstract

Academic labs have been responsible for virtually all of the basic science discoveries that translate into the discovery and development of innovative new medicines. There is a growing concern that large pharmaceutical and biotechnology companies are not able to sustain research pipelines that bring new compounds into drug development that translate into innovative new medicines, especially in areas with high unmet medical need. To address the needs of patients, caregivers, and society, academic labs have played and can continue to play an important role at one or more stages in the development of innovative medicines, both directly and through collaborations with researchers in pharmaceutical and biotechnology companies. Collaboration is in the best interests of patients and society if it accelerates the translation of basic science discoveries to new medicines that address unmet medical needs.

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Year:  2010        PMID: 20445199     DOI: 10.1126/scitranslmed.3000169

Source DB:  PubMed          Journal:  Sci Transl Med        ISSN: 1946-6234            Impact factor:   17.956


  24 in total

Review 1.  Prions.

Authors:  David W Colby; Stanley B Prusiner
Journal:  Cold Spring Harb Perspect Biol       Date:  2011-01-01       Impact factor: 10.005

2.  EATRIS, a vision for translational research in Europe.

Authors:  Regina Becker; Guus A M S van Dongen
Journal:  J Cardiovasc Transl Res       Date:  2011-05-05       Impact factor: 4.132

Review 3.  Impact of high-throughput screening in biomedical research.

Authors:  Ricardo Macarron; Martyn N Banks; Dejan Bojanic; David J Burns; Dragan A Cirovic; Tina Garyantes; Darren V S Green; Robert P Hertzberg; William P Janzen; Jeff W Paslay; Ulrich Schopfer; G Sitta Sittampalam
Journal:  Nat Rev Drug Discov       Date:  2011-03       Impact factor: 84.694

4.  Oral Drug Delivery Technologies-A Decade of Developments.

Authors:  G Kaur; M Arora; M N V Ravi Kumar
Journal:  J Pharmacol Exp Ther       Date:  2019-04-22       Impact factor: 4.030

5.  EATRIS, a European initiative to boost translational biomedical research.

Authors:  Guus Ams van Dongen; Anton E Ussi; Frank H de Man; Giovanni Migliaccio
Journal:  Am J Nucl Med Mol Imaging       Date:  2013-03-08

Review 6.  Lost but making progress--Where will new analgesic drugs come from?

Authors:  David Borsook; Richard Hargreaves; Chas Bountra; Frank Porreca
Journal:  Sci Transl Med       Date:  2014-08-13       Impact factor: 17.956

Review 7.  Mitigating risk in academic preclinical drug discovery.

Authors:  Jayme L Dahlin; James Inglese; Michael A Walters
Journal:  Nat Rev Drug Discov       Date:  2015-04       Impact factor: 84.694

8.  The path from bench to bedside: considerations before starting the journey.

Authors:  Mason Wright Freeman; Andrew P Dervan
Journal:  J Investig Med       Date:  2011-06       Impact factor: 2.895

9.  The Alabama Drug Discovery Alliance: a collaborative partnership to facilitate academic drug discovery.

Authors:  Maaike Everts; W Blaine Knight; David R Harris; John A Secrist; Richard J Whitley
Journal:  Pharm Res       Date:  2011-03-30       Impact factor: 4.200

10.  Playing well with others! Initiating and sustaining successful collaborations between industry, academia and government.

Authors:  Craig J Thomas; John C McKew
Journal:  Curr Top Med Chem       Date:  2014       Impact factor: 3.295

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