Literature DB >> 20443855

Myocardial Fas and cytokine expression in end-stage heart failure: impact of LVAD support.

Maninder S Bedi1, Rene J Alvarez, Toru Kubota, Richard Sheppard, Robert L Kormos, Michael P Siegenthaler, Arthur M Feldman, Charles F McTiernan, Dennis M McNamara.   

Abstract

Left ventricular assist device (LVAD) support may facilitate myocardial recovery. We evaluated the impact of LVAD support on Fas expression in a cohort with end-stage heart failure. Myocardial gene expression was assessed pre- and post-LVAD by RNase protection assay and compared to control donor hearts. The expression of Fas is markedly elevated at the time of LVAD support and is tightly correlated with TNF expression. While interleukin (IL)-6 was significantly reduced by LVAD support, the impact of support on Fas was highly variable and tightly linked to tumor necrosis factor (TNF). The role of Fas in predicting recovery after LVAD support requires further investigation.

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Year:  2008        PMID： 20443855      PMCID： PMC5350672          DOI： 10.1111/j.1752-8062.2008.00056.x

Source DB:  PubMed          Journal:  Clin Transl Sci        ISSN： 1752-8054            Impact factor:   4.689


  28 in total

Review 1.  Apoptosis in the cardiovascular system.

Authors:  Martin R Bennett
Journal:  Heart       Date:  2002-05       Impact factor: 5.994

2.  Reduction in Fas/APO-1 plasma concentrations correlates with improvement in left ventricular function in patients with idiopathic dilated cardiomyopathy treated with pentoxifylline.

Authors:  D Skudicky; K Sliwa; A Bergemann; G Candy; P Sareli
Journal:  Heart       Date:  2000-10       Impact factor: 5.994

3.  Myocardial recovery using ventricular assist devices: prevalence, clinical characteristics, and outcomes.

Authors:  Marc A Simon; Robert L Kormos; Srinivas Murali; Pradeep Nair; Michael Heffernan; John Gorcsan; Stephen Winowich; Dennis M McNamara
Journal:  Circulation       Date:  2005-08-30       Impact factor: 29.690

4.  Soluble TNF binding proteins modulate the negative inotropic properties of TNF-alpha in vitro.

Authors:  S Kapadia; G Torre-Amione; T Yokoyama; D L Mann
Journal:  Am J Physiol       Date:  1995-02

5.  Myocardial tumor necrosis factor-alpha expression does not correlate with clinical indices of heart failure in patients on left ventricular assist device support.

Authors:  P Razeghi; M Mukhopadhyay; T J Myers; J N Williams; C S Moravec; O H Frazier; H Taegtmeyer
Journal:  Ann Thorac Surg       Date:  2001-12       Impact factor: 4.330

6.  The cardiac Fas (APO-1/CD95) Receptor/Fas ligand system : relation to diastolic wall stress in volume-overload hypertrophy in vivo and activation of the transcription factor AP-1 in cardiac myocytes.

Authors:  K C Wollert; J Heineke; J Westermann; M Lüdde; B Fiedler; W Zierhut; D Laurent; M K Bauer; K Schulze-Osthoff; H Drexler
Journal:  Circulation       Date:  2000-03-14       Impact factor: 29.690

7.  Quantitative myocardial cytokine expression and activation of the apoptotic pathway in patients who require left ventricular assist devices.

Authors:  E J Birks; N Latif; V Owen; C Bowles; L E Felkin; A J Mullen; A Khaghani; P J Barton; J M Polak; J R Pepper; N R Banner; M H Yacoub
Journal:  Circulation       Date:  2001-09-18       Impact factor: 29.690

8.  Myocardial expression of fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy.

Authors:  Richard Sheppard; Maninder Bedi; Toru Kubota; Marc J Semigran; William Dec; Richard Holubkov; Arthur M Feldman; Warren D Rosenblum; Charles F McTiernan; Dennis M McNamara
Journal:  J Am Coll Cardiol       Date:  2005-09-20       Impact factor: 24.094

9.  Molecular signature of recovery following combination left ventricular assist device (LVAD) support and pharmacologic therapy.

Authors:  Jennifer L Hall; Emma J Birks; Suzanne Grindle; Martin E Cullen; Paul J Barton; James E Rider; Sangjin Lee; Subash Harwalker; Ami Mariash; Neeta Adhikari; Nathan J Charles; Leanne E Felkin; Sean Polster; Robert S George; Leslie W Miller; Magdi H Yacoub
Journal:  Eur Heart J       Date:  2006-11-28       Impact factor: 29.983

10.  Decreased expression of tumor necrosis factor-alpha in failing human myocardium after mechanical circulatory support : A potential mechanism for cardiac recovery.

Authors:  G Torre-Amione; S J Stetson; K A Youker; J B Durand; B Radovancevic; R M Delgado; O H Frazier; M L Entman; G P Noon
Journal:  Circulation       Date:  1999-09-14       Impact factor: 29.690
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  5 in total

1.  Left ventricular remodeling and myocardial recovery on mechanical circulatory support.

Authors:  Marc A Simon; Brian A Primack; Jeffrey Teuteberg; Robert L Kormos; Christian Bermudez; Yoshiya Toyoda; Hemal Shah; John Gorcsan; Dennis M McNamara
Journal:  J Card Fail       Date:  2009-11-14       Impact factor: 5.712

Review 2.  Biomarkers in heart failure: the past, current and future.

Authors:  Michael Sarhene; Yili Wang; Jing Wei; Yuting Huang; Min Li; Lan Li; Enoch Acheampong; Zhou Zhengcan; Qin Xiaoyan; Xu Yunsheng; Mao Jingyuan; Gao Xiumei; Fan Guanwei
Journal:  Heart Fail Rev       Date:  2019-11       Impact factor: 4.214

Review 3.  Reverse Remodeling With Left Ventricular Assist Devices.

Authors:  Daniel Burkhoff; Veli K Topkara; Gabriel Sayer; Nir Uriel
Journal:  Circ Res       Date:  2021-05-13       Impact factor: 23.213

Review 4.  The Inflammatory Response to Ventricular Assist Devices.

Authors:  Gemma Radley; Ina Laura Pieper; Sabrina Ali; Farah Bhatti; Catherine A Thornton
Journal:  Front Immunol       Date:  2018-11-15       Impact factor: 7.561

5.  Degenerative changes of the aortic valve during left ventricular assist device support.

Authors:  Mareike Barth; Linus Mrozek; Naima Niazy; Jessica Isabel Selig; Udo Boeken; Yukiharu Sugimura; Nikolaos Kalampokas; Patrick Horn; Ralf Westenfeld; Patric Kröpil; Hug Aubin; Artur Lichtenberg; Payam Akhyari
Journal:  ESC Heart Fail       Date:  2021-12-21
  5 in total

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