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Literature DB >> 20440555

The role of excitatory amino acid transporters in cerebral ischemia.

Abstract

Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of ischemia brain injury. The regulation of glutamate neurotransmission is carried out by excitatory amino acid transporters (EAATs) that act through reuptake of glutamate into cells. EAATs may also release glutamate into the extracellular space in a calcium-independent manner during ischemia and dysfunction of EAATs is specifically implicated in the pathology of cerebral ischemia. Recent studies show that up-regulation of EAAT2 provides neuroprotection during ischemic insult. This review summarizes current knowledge regarding the role of EAATs in cerebral ischemia.

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Year: 2010 PMID： 20440555 DOI： 10.1007/s11064-010-0178-3

Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996

81 in total

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Journal: J Biol Chem Date: 2008-03-07 Impact factor: 5.157

23 in total

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Authors: Marcelo Ganzella; Enderson Dias Alves de Oliveira; Daniel Diniz Comassetto; Fernanda Cechetti; Victor Hermes Cereser; Júlia Dubois Moreira; Gisele Hansel; Roberto Farina Almeida; Denise Barbosa Ramos; Yanier Nuñes Figueredo; Debora Guerini Souza; Jean Pierre Oses; Paulo Valdeci Worm; Matilde Achaval; Carlos Alexandre Netto; Diogo Onofre Souza
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Journal: Mol Cell Proteomics Date: 2017-11-13 Impact factor: 5.911

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Authors: Yan Deng; Minghuan Wang; Wei Wang; Chao Ma; Nongyue He
Journal: Neurochem Res Date: 2012-12-11 Impact factor: 3.996