AIMS: Our study was conducted to evaluate the potent protective effects of oral administration of probiotic Lactobacillus strains against influenza virus (Flu) infection in a mouse model. METHOD AND RESULTS: Lyophilized Lactobacillus rhamnosus GG (LGG) and Lactobacillus gasseri TMC0356 (TMC0356) were orally administered to BALB/c mice for 19 days. The test mice were intranasally infected with Flu A/PR/8/34 (H1N1) on day 14, and any changes in clinical symptoms were monitored. After 6 days of infection, the mice were killed and pulmonary virus titres were determined. The clinical symptom scores of mice administered oral LGG and TMC0356 were significantly ameliorated, compared to those of the control mice (P < 0.01). The pulmonary virus titres of the mice fed LGG and TMC0356 were also significantly decreased compared to those of control mice (P < 0.05). CONCLUSIONS: These results indicate that oral administration of lactobacilli, such as LGG and TMC0356, might protect a host animal against Flu infection. SIGNIFICANCE AND IMPACT OF THE STUDY: These results demonstrate that oral administration of selected lactobacilli might protect host animals from Flu infection by interactions with gut immunity.
AIMS: Our study was conducted to evaluate the potent protective effects of oral administration of probiotic Lactobacillus strains against influenza virus (Flu) infection in a mouse model. METHOD AND RESULTS: Lyophilized Lactobacillus rhamnosus GG (LGG) and Lactobacillus gasseriTMC0356 (TMC0356) were orally administered to BALB/c mice for 19 days. The test mice were intranasally infected with Flu A/PR/8/34 (H1N1) on day 14, and any changes in clinical symptoms were monitored. After 6 days of infection, the mice were killed and pulmonary virus titres were determined. The clinical symptom scores of mice administered oral LGG and TMC0356 were significantly ameliorated, compared to those of the control mice (P < 0.01). The pulmonary virus titres of the mice fed LGG and TMC0356 were also significantly decreased compared to those of control mice (P < 0.05). CONCLUSIONS: These results indicate that oral administration of lactobacilli, such as LGG and TMC0356, might protect a host animal against Flu infection. SIGNIFICANCE AND IMPACT OF THE STUDY: These results demonstrate that oral administration of selected lactobacilli might protect host animals from Flu infection by interactions with gut immunity.
Authors: Theo S Plantinga; Wendy W C van Maren; Jeroen van Bergenhenegouwen; Marjolijn Hameetman; Stefan Nierkens; Cor Jacobs; Dirk J de Jong; Leo A B Joosten; Belinda van't Land; Johan Garssen; Gosse J Adema; Mihai G Netea Journal: Clin Vaccine Immunol Date: 2011-02-02
Authors: Jin Zhang; Heather L Tyler; Mona H Haron; Colin R Jackson; David S Pasco; Nirmal D Pugh Journal: Food Funct Date: 2019-12-11 Impact factor: 5.396
Authors: David Groeger; Elisa Schiavi; Ray Grant; Magdalena Kurnik-Łucka; David Michalovich; Rick Williamson; Soren Beinke; Barry Kiely; Cezmi A Akdis; Edith M Hessel; Fergus Shanahan; Liam O' Mahony Journal: EBioMedicine Date: 2020-09-11 Impact factor: 8.143
Authors: Maria Eugenia Dieterle; Charles Bowman; Carlos Batthyany; Esteban Lanzarotti; Adrián Turjanski; Graham Hatfull; Mariana Piuri Journal: Appl Environ Microbiol Date: 2014-09-12 Impact factor: 4.792
Authors: Victor B Hsue; Kyohei Itamura; Arthur W Wu; Elisa A Illing; Kevin J Sokoloski; Bree A Weaver; Benjamin P Anthony; Nathan Hughes; Jonathan Y Ting; Thomas S Higgins Journal: Adv Exp Med Biol Date: 2021 Impact factor: 2.622
Authors: Noura Kechaou; Florian Chain; Jean-Jacques Gratadoux; Sébastien Blugeon; Nicolas Bertho; Christophe Chevalier; Ronan Le Goffic; Stéphanie Courau; Pascal Molimard; Jean Marc Chatel; Philippe Langella; Luis G Bermúdez-Humarán Journal: Appl Environ Microbiol Date: 2012-12-21 Impact factor: 4.792