| Literature DB >> 34279838 |
Victor B Hsue1, Kyohei Itamura1, Arthur W Wu1, Elisa A Illing2, Kevin J Sokoloski3, Bree A Weaver4, Benjamin P Anthony2, Nathan Hughes5, Jonathan Y Ting2, Thomas S Higgins6,7.
Abstract
With the largest viral loads in both symptomatic and asymptomatic patients with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) present in the oral and nasal cavities, agents that act on these two areas have the potential for large therapeutic and prophylactic benefit. A literature review was conducted to elucidate the possible agents useful in treatment of SARS-CoV-2. These agents were evaluated for their current applications, adverse reactions, their current state of study, and any future considerations in their management of coronavirus disease 2019 (COVID-2019). Our review has found that, while there are many promising agents with proven efficacy in their in-vitro efficacy against SARS-CoV-2, more clinical trials and in-vivo studies, as well as safety trials, must be conducted before these agents can be effectively implemented.Entities:
Keywords: Antiviral agents; COVID-19; Coronavirus; Nasal; Nasopharynx; Oral; Public health; Severe acute respiratory syndrome coronavirus 2; Topical
Mesh：
Substances：
Year: 2021 PMID： 34279838 DOI： 10.1007/978-3-030-71697-4_14
Source DB: PubMed Journal: Adv Exp Med Biol ISSN： 0065-2598 Impact factor: 2.622