Literature DB >> 20437568

Endogenous neurosteroid synthesis modulates seizure frequency.

Courtney Lawrence1, Brandon Scott Martin, Chengsan Sun, John Williamson, Jaideep Kapur.   

Abstract

Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.

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Year:  2010        PMID： 20437568      PMCID： PMC2918659          DOI： 10.1002/ana.21989

Source DB:  PubMed          Journal:  Ann Neurol        ISSN： 0364-5134            Impact factor:   10.422


  19 in total

1.  Neuroactive steroids reduce neuronal excitability by selectively enhancing tonic inhibition mediated by delta subunit-containing GABAA receptors.

Authors:  Brandon M Stell; Stephen G Brickley; C Y Tang; Mark Farrant; Istvan Mody
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-17       Impact factor: 11.205

2.  Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.

Authors:  Z Mtchedlishvili; E H Bertram; J Kapur
Journal:  J Physiol       Date:  2001-12-01       Impact factor: 5.182

3.  Neuroactive steroids protect against pilocarpine- and kainic acid-induced limbic seizures and status epilepticus in mice.

Authors:  T G Kokate; A L Cohen; E Karp; M A Rogawski
Journal:  Neuropharmacology       Date:  1996       Impact factor: 5.250

4.  Seizure exacerbation associated with inhibition of progesterone metabolism.

Authors:  Andrew G Herzog; Cheryl A Frye
Journal:  Ann Neurol       Date:  2003-03       Impact factor: 10.422

5.  Neurosteroid withdrawal model of perimenstrual catamenial epilepsy.

Authors:  D S Reddy; H Y Kim; M A Rogawski
Journal:  Epilepsia       Date:  2001-03       Impact factor: 5.864

Review 6.  The dentate gyrus as a control point for seizures in the hippocampus and beyond.

Authors:  E W Lothman; J L Stringer; E H Bertram
Journal:  Epilepsy Res Suppl       Date:  1992

7.  Altered expression of the delta subunit of the GABAA receptor in a mouse model of temporal lobe epilepsy.

Authors:  Zechun Peng; Christine S Huang; Brandon M Stell; Istvan Mody; Carolyn R Houser
Journal:  J Neurosci       Date:  2004-09-29       Impact factor: 6.167

8.  Anticonvulsant activity of neurosteroids: correlation with gamma-aminobutyric acid-evoked chloride current potentiation.

Authors:  T G Kokate; B E Svensson; M A Rogawski
Journal:  J Pharmacol Exp Ther       Date:  1994-09       Impact factor: 4.030

9.  Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one.

Authors:  D Belelli; M B Bolger; K W Gee
Journal:  Eur J Pharmacol       Date:  1989-07-18       Impact factor: 4.432

10.  Anticonvulsant activity of progesterone and neurosteroids in progesterone receptor knockout mice.

Authors:  D S Reddy; D C Castaneda; B W O'Malley; M A Rogawski
Journal:  J Pharmacol Exp Ther       Date:  2004-02-24       Impact factor: 4.030
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  26 in total

Review 1.  Sex and hormonal influences on seizures and epilepsy.

Authors:  Jana Velíšková; Kara A Desantis
Journal:  Horm Behav       Date:  2012-04-04       Impact factor: 3.587

2.  Neurosteroids on the epilepsy chessboard-keeping seizures in check.

Authors:  Michael A Rogawski
Journal:  Epilepsy Curr       Date:  2010-11       Impact factor: 7.500

3.  Progesterone vs placebo therapy for women with epilepsy: A randomized clinical trial.

Authors:  A G Herzog; K M Fowler; S D Smithson; L A Kalayjian; C N Heck; M R Sperling; J D Liporace; C L Harden; B A Dworetzky; P B Pennell; J M Massaro
Journal:  Neurology       Date:  2012-05-30       Impact factor: 9.910

4.  Role of neurosteroids in the anticonvulsant activity of midazolam.

Authors:  Ashish Dhir; Michael A Rogawski
Journal:  Br J Pharmacol       Date:  2012-04       Impact factor: 8.739

Review 5.  Neurosteroids and GABAergic signaling in health and disease.

Authors:  Georgina MacKenzie; Jamie Maguire
Journal:  Biomol Concepts       Date:  2013-02

6.  A novel therapeutic approach for treatment of catamenial epilepsy.

Authors:  Suchitra Joshi; Huayu Sun; Karthik Rajasekaran; John Williamson; Edward Perez-Reyes; Jaideep Kapur
Journal:  Neurobiol Dis       Date:  2017-12-21       Impact factor: 5.996

7.  A mouse kindling model of perimenstrual catamenial epilepsy.

Authors:  Doodipala Samba Reddy; Jordan Gould; O Gangisetty
Journal:  J Pharmacol Exp Ther       Date:  2012-03-20       Impact factor: 4.030

8.  Temporal lobe epilepsy exacerbation during pharmacological inhibition of endogenous neurosteroid synthesis.

Authors:  Matteo Pugnaghi; Giulia Monti; Giuseppe Biagini; Stefano Meletti
Journal:  BMJ Case Rep       Date:  2013-02-19

Review 9.  Neurosteroids and their role in sex-specific epilepsies.

Authors:  Doodipala Samba Reddy
Journal:  Neurobiol Dis       Date:  2014-06-21       Impact factor: 5.996

10.  The brain, seizures and epilepsy throughout life: understanding a moving target.

Authors:  Tallie Z Baram
Journal:  Epilepsy Curr       Date:  2012-07       Impact factor: 7.500
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