Literature DB >> 2792198

Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one.

D Belelli1, M B Bolger, K W Gee.   

Abstract

5 alpha-Pregnan-3 alpha-ol-20-one (3 alpha-OH-DHP) is a naturally occurring metabolite of progesterone that can modulate brain excitability through a specific steroid recognition site on the GABA/benzodiazepine receptor-chloride ionophore complex. The anticonvulsant properties of 3 alpha-OH-DHP were determined using standardized anticonvulsant screening tests in mice. This steroid was found to be effective against metrazol-, (+)-bicuculline- and picrotoxin-induced seizures. The steroid has maximum potency against (+)-bicuculline-induced convulsions and no activity against maximal electroshock and strychnine-induced seizures. These findings support the hypothesis that therapeutically useful anticonvulsant steroids active at the putative steroid recognition site associated with the GABA/benzodiazepine receptor-chloride ionophore complex can be identified.

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Year:  1989        PMID： 2792198     DOI： 10.1016/0014-2999(89)90077-0

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  70 in total

1.  Effect of phosphamidon on convulsive behavior and biochemical parameters: modulation by progesterone and 4'-chlorodiazepam in rats.

Authors:  Vikas Joshi; Tarun Arora; Ashish K Mehta; Amit K Sharma; Naveen Rathor; Kapil D Mehta; Prabha Mahajan; Pramod K Mediratta; Basu D Banerjee; Krishna K Sharma
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2010-08-25       Impact factor: 3.000

2.  Neurosteroids and self-reported pain in veterans who served in the U.S. Military after September 11, 2001.

Authors:  Jason D Kilts; Larry A Tupler; Francis J Keefe; Victoria M Payne; Robert M Hamer; Jennifer C Naylor; Rohana P Calnaido; Rajendra A Morey; Jennifer L Strauss; Gillian Parke; Mark W Massing; Nagy A Youssef; Lawrence J Shampine; Christine E Marx
Journal:  Pain Med       Date:  2010-08-23       Impact factor: 3.750

3.  Voluntary ethanol consumption reduces GABAergic neuroactive steroid (3α,5α)3-hydroxypregnan-20-one (3α,5α-THP) in the amygdala of the cynomolgus monkey.

Authors:  Matthew C Beattie; Antoniette M Maldonado-Devincci; Patrizia Porcu; Todd K O'Buckley; James B Daunais; Kathleen A Grant; A Leslie Morrow
Journal:  Addict Biol       Date:  2015-12-02       Impact factor: 4.280

Review 4.  Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor.

Authors:  N C Lan; M B Bolger; K W Gee
Journal:  Neurochem Res       Date:  1991-03       Impact factor: 3.996

Review 5.  The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female.

Authors:  Helen E Scharfman; Neil J MacLusky
Journal:  Epilepsia       Date:  2006-09       Impact factor: 5.864

6.  S-norfluoxetine microinfused into the basolateral amygdala increases allopregnanolone levels and reduces aggression in socially isolated mice.

Authors:  Marianela Nelson; Graziano Pinna
Journal:  Neuropharmacology       Date:  2010-10-29       Impact factor: 5.250

Review 7.  Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies.

Authors:  Patrizia Porcu; A Leslie Morrow
Journal:  Psychopharmacology (Berl)       Date:  2014-04-26       Impact factor: 4.530

8.  Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor.

Authors:  Helen E Scharfman; Thomas C Mercurio; Jeffrey H Goodman; Marlene A Wilson; Neil J MacLusky
Journal:  J Neurosci       Date:  2003-12-17       Impact factor: 6.167

9.  Comparative behavioral characterization of the neuroactive steroids 3 alpha-OH,5 alpha-pregnan-20-one and 3 alpha-OH,5 beta-pregnan-20-one in rodents.

Authors:  S Wieland; J D Belluzzi; L Stein; N C Lan
Journal:  Psychopharmacology (Berl)       Date:  1995-03       Impact factor: 4.530

Review 10.  Progress in neuroprotective strategies for preventing epilepsy.

Authors:  Munjal M Acharya; Bharathi Hattiangady; Ashok K Shetty
Journal:  Prog Neurobiol       Date:  2007-12-08       Impact factor: 11.685
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