OBJECTIVE: Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular disease is still controversial. As diabetes and uremia make the role of fetuin-A in cardiovascular disease uncertain, we investigated the association between fetuin-A and calcified coronary artery disease in participants without diabetes and renal dysfunction. METHODS: Serum fetuin-A levels were measured in 92 participants who underwent coronary angiography. The number of diseased vessels and the presence of calcification were evaluated. RESULTS: Fetuin-A levels significantly decreased in patients with advanced three-vessel disease compared with those without stenosis (245.5+/-50.9, 289.0+/-71.8 microg/ml, respectively; P<0.05). Likewise, fetuin-A levels were significantly lower in patients with coronary artery calcification compared with those without coronary artery calcification (257.1+/-49.7, 288.0+/-63.1 microg/ml, respectively; P = 0.010). Multivariate logistic regression analysis revealed that fetuin-A levels inversely correlated with the presence of coronary artery calcification (odds ratio: 0.54; 95% confidence interval: 0.31-0.92; P = 0.025). CONCLUSION: Serum fetuin-A levels inversely correlated with advanced calcified coronary artery disease.
OBJECTIVE:Fetuin-A is a circulating glycoprotein that is involved in various stages of atherosclerosis. Despite the fact that emerging evidence suggests fetuin-A acts as a calcification inhibitor that protects against advanced calcified atherosclerosis in dialyzed patients, the role of fetuin-A in cardiovascular disease is still controversial. As diabetes and uremia make the role of fetuin-A in cardiovascular disease uncertain, we investigated the association between fetuin-A and calcified coronary artery disease in participants without diabetes and renal dysfunction. METHODS: Serum fetuin-A levels were measured in 92 participants who underwent coronary angiography. The number of diseased vessels and the presence of calcification were evaluated. RESULTS:Fetuin-A levels significantly decreased in patients with advanced three-vessel disease compared with those without stenosis (245.5+/-50.9, 289.0+/-71.8 microg/ml, respectively; P<0.05). Likewise, fetuin-A levels were significantly lower in patients with coronary artery calcification compared with those without coronary artery calcification (257.1+/-49.7, 288.0+/-63.1 microg/ml, respectively; P = 0.010). Multivariate logistic regression analysis revealed that fetuin-A levels inversely correlated with the presence of coronary artery calcification (odds ratio: 0.54; 95% confidence interval: 0.31-0.92; P = 0.025). CONCLUSION: Serum fetuin-A levels inversely correlated with advanced calcified coronary artery disease.
Authors: Joachim H Ix; Elizabeth Barrett-Connor; Christina L Wassel; Kevin Cummins; Jaclyn Bergstrom; Lori B Daniels; Gail A Laughlin Journal: J Am Coll Cardiol Date: 2011-11-29 Impact factor: 24.094
Authors: Joachim H Ix; Mary L Biggs; Kenneth J Mukamal; Jorge R Kizer; Susan J Zieman; David S Siscovick; Dariush Mozzaffarian; Majken K Jensen; Lauren Nelson; Neil Ruderman; Luc Djousse Journal: Circulation Date: 2012-04-17 Impact factor: 29.690
Authors: Marcel Roos; Dimitrios Oikonomou; Maximilian von Eynatten; Peter B Luppa; Uwe Heemann; Jens Lutz; Marcus Baumann; Peter P Nawroth; Angelika Bierhaus; Per M Humpert Journal: Cardiovasc Diabetol Date: 2010-09-07 Impact factor: 9.951