| Literature DB >> 20436163 |
Edward C Keystone1, Carl F Ware.
Abstract
Tumor necrosis factor (TNF) plays a crucial role in the pathogenesis of immune-mediated inflammatory diseases (IMID). As a result, the inhibition of TNF is an important therapeutic avenue in the treatment of these pathophysiologically diverse disease states. This section discusses TNF, its receptors, and its role in immunoregulation and inflammation, as well as the currently available anti-TNF-based therapies.Entities:
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Year: 2010 PMID: 20436163 DOI: 10.3899/jrheum.091463
Source DB: PubMed Journal: J Rheumatol Suppl ISSN: 0380-0903