João D Fontes1, Faisal Rahman2, Sean Lacey3, Martin G Larson4, Ramachandran S Vasan5, Emelia J Benjamin5, William S Harris6, Sander J Robins1. 1. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA; Department of Cardiology and Preventive Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Medicine, Boston University School of Medicine, Boston, MA, USA. 2. Boston University Medical Center, Boston, MA 02118, USA. 3. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA. 4. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA; Department of Mathematics and Statistics, Boston University, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. 5. National Heart Lung and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA, USA; Department of Cardiology and Preventive Medicine, Boston University School of Medicine, Boston, MA, USA; Department of Medicine, Boston University School of Medicine, Boston, MA, USA; Epidemiology Department, Boston University School of Public Health, Boston, MA, USA. 6. Department of Medicine, Sanford School of Medicine, University of South Dakota, and OmegaQuant Analytics, LLC, 5009 W. 12th St, Ste 8, Sioux Falls, SD 57106, USA. Electronic address: bill@omegaquant.com.
Abstract
INTRODUCTION: Inflammation and inflammatory biomarkers have emerged as integral components and predictors of incident cardiovascular (CV) disease. Omega-3 fatty acids, particularly eicosapentaenoic and docosahexaenoic acids (EPA and DHA) have anti-inflammatory properties, and have been variably associated with lower blood pressure, favorable blood lipid changes, and reduced CV events. METHODS AND RESULTS: We examined the cross-sectional association of red blood cell (RBC) fatty acids, representative of body membrane fatty acid composition, with 10 biomarkers active in multiple inflammatory pathways in 2724 participants (mean age 66 ± 9 years, 54% women, 8% minorities) from the Framingham Offspring and minority Omni Cohorts. After multivariable adjustment, the RBC EPA and DHA content was inversely correlated (all P ≤ 0.001) with 8 biomarkers: urinary isoprostanes (r = -0.16); and soluble interleukin-6 (r = -0.10); C-reactive protein (r = -0.08); tumor necrosis factor receptor 2 (r = -0.08); intercellular adhesion molecule-1 (r = -0.08); P-selectin (r = -0.06); lipoprotein-associated phospholipase-A2 mass (r = -0.11) and activity (r = -0.08). The correlations for monocyte chemoattractant protein-1 was -0.05, P = 0.006 and osteoprotegerin (r = -0.06, P = 0.002) were only nominally significant. CONCLUSION: In our large community-based study, we observed modest inverse associations between several types of inflammatory biomarkers with RBC omega-3 fatty acid levels. Our findings are consistent with the hypothesis that omega-3 fatty acids have anti-inflammatory properties.
INTRODUCTION:Inflammation and inflammatory biomarkers have emerged as integral components and predictors of incident cardiovascular (CV) disease. Omega-3 fatty acids, particularly eicosapentaenoic and docosahexaenoic acids (EPA and DHA) have anti-inflammatory properties, and have been variably associated with lower blood pressure, favorable blood lipid changes, and reduced CV events. METHODS AND RESULTS: We examined the cross-sectional association of red blood cell (RBC) fatty acids, representative of body membrane fatty acid composition, with 10 biomarkers active in multiple inflammatory pathways in 2724 participants (mean age 66 ± 9 years, 54% women, 8% minorities) from the Framingham Offspring and minority Omni Cohorts. After multivariable adjustment, the RBC EPA and DHA content was inversely correlated (all P ≤ 0.001) with 8 biomarkers: urinary isoprostanes (r = -0.16); and soluble interleukin-6 (r = -0.10); C-reactive protein (r = -0.08); tumor necrosis factor receptor 2 (r = -0.08); intercellular adhesion molecule-1 (r = -0.08); P-selectin (r = -0.06); lipoprotein-associated phospholipase-A2 mass (r = -0.11) and activity (r = -0.08). The correlations for monocyte chemoattractant protein-1 was -0.05, P = 0.006 and osteoprotegerin (r = -0.06, P = 0.002) were only nominally significant. CONCLUSION: In our large community-based study, we observed modest inverse associations between several types of inflammatory biomarkers with RBC omega-3 fatty acid levels. Our findings are consistent with the hypothesis that omega-3 fatty acids have anti-inflammatory properties.
Authors: William S Harris; James V Pottala; Ramachandran S Vasan; Martin G Larson; Sander J Robins Journal: J Nutr Date: 2012-05-23 Impact factor: 4.798
Authors: Greta Lee Splansky; Diane Corey; Qiong Yang; Larry D Atwood; L Adrienne Cupples; Emelia J Benjamin; Ralph B D'Agostino; Caroline S Fox; Martin G Larson; Joanne M Murabito; Christopher J O'Donnell; Ramachandran S Vasan; Philip A Wolf; Daniel Levy Journal: Am J Epidemiol Date: 2007-03-19 Impact factor: 4.897
Authors: Thomas J Wang; Philimon Gona; Martin G Larson; Daniel Levy; Emelia J Benjamin; Geoffrey H Tofler; Paul F Jacques; James B Meigs; Nader Rifai; Jacob Selhub; Sander J Robins; Christopher Newton-Cheh; Ramachandran S Vasan Journal: Hypertension Date: 2007-01-22 Impact factor: 10.190
Authors: Renate Schnabel; Martin G Larson; Josée Dupuis; Kathryn L Lunetta; Izabella Lipinska; James B Meigs; Xiaoyan Yin; Jian Rong; Joseph A Vita; Christopher Newton-Cheh; Daniel Levy; John F Keaney; Ramachandran S Vasan; Gary F Mitchell; Emelia J Benjamin Journal: Hypertension Date: 2008-04-21 Impact factor: 10.190
Authors: Laura M Drudi; Melinda S Schaller; Jade Hiramoto; Warren Gasper; William S Harris; Nancy K Hills; S Marlene Grenon Journal: J Surg Res Date: 2016-11-11 Impact factor: 2.192
Authors: William S Harris; Juhua Luo; James V Pottala; Mark A Espeland; Karen L Margolis; Joann E Manson; Lu Wang; Theodore M Brasky; Jennifer G Robinson Journal: J Clin Lipidol Date: 2017-01-12 Impact factor: 4.766
Authors: Ashley M Eskew; Kelly C Wormer; Michelle L Matthews; H James Norton; Margaret A Papadakis; Bradley S Hurst Journal: J Assist Reprod Genet Date: 2017-09-13 Impact factor: 3.412
Authors: Janine Tittus; Marie Theres Huber; Klaus Storck; Anton Köhler; Jan M Köhler; Thomas von Arnim; Clemens von Schacky Journal: J Clin Sleep Med Date: 2017-10-15 Impact factor: 4.062
Authors: Johanna T Dwyer; Kristin H Rubin; Kevin L Fritsche; Tricia L Psota; DeAnn J Liska; William S Harris; Scott J Montain; Barbara J Lyle Journal: Adv Nutr Date: 2016-07-15 Impact factor: 8.701
Authors: Eric J Kuklinski; Milton M Hom; Gui-Shuang Ying; Meng C Lin; Robert S Chapkin; Richard Jones; Ann Moser; Ka Yeun Kim; Maureen G Maguire; Penny A Asbell Journal: Eye Contact Lens Date: 2021-01-01 Impact factor: 3.152