Analysis of the effects of astigmatism and misalignment on corneal surface reconstruction from photokeratoscopic data.

This article presents a general method of error analysis for reconstruction algorithms employed by corneal topography systems and applies this method to assess the accuracy of the Wang reconstruction algorithms. Using mathematical surface reconstructions, the method detects artifacts introduced in topographic analysis by astigmatism and misalignment. For the Wang algorithms, error introduced by astigmatism was less than 1% of the true value for surfaces with more than 10.00 diopters of astigmatism. A 1-mm translational misalignment of the analyzed surface introduced error of no more than 1.3%. Errors caused by rotational misalignment were less than 3% for misalignments of 5 degrees or less. It is concluded from the error analysis method that the Wang algorithms are sufficiently accurate for use in the analysis of corneal topography. Similar analyses need to be accomplished for the validation of commercially available corneal topography systems.