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Literature DB >> 20435486

Laserspray ionization (LSI) ion mobility spectrometry (IMS) mass spectrometry.

Abstract

A simple device is described for desolvation of highly charged matrix/analyte clusters produced by laser ablation leading to multiply charged ions that are analyzed by ion mobility spectrometry-mass spectrometry. Thus, for example, highly charged ions of ubiquitin and lysozyme are cleanly separated in the gas phase according to size and mass (shape and molecular weight) as well as charge using Tri-Wave ion mobility technology coupled to mass spectrometry. This contribution confirms the mechanistic argument that desolvation is necessary to produce multiply charged matrix-assisted laser desorption/ionization (MALDI) ions and points to how these ions can be routinely formed on any atmospheric pressure mass spectrometer. Copyright 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

Entities: Disease Gene

Year: 2010 PMID： 20435486 DOI： 10.1016/j.jasms.2010.03.039

Source DB: PubMed Journal: J Am Soc Mass Spectrom ISSN： 1044-0305 Impact factor: 3.109

16 in total

Review 1. A perspective on MALDI alternatives-total solvent-free analysis and electron transfer dissociation of highly charged ions by laserspray ionization.

Authors: Sarah Trimpin
Journal: J Mass Spectrom Date: 2010-05 Impact factor: 1.982

2. Evidence for many resolvable structures within conformation types of electrosprayed ubiquitin ions.

Authors: Stormy L Koeniger; Samuel I Merenbloom; David E Clemmer
Journal: J Phys Chem B Date: 2006-04-06 Impact factor: 2.991

3. Transfer of structural elements from compact to extended states in unsolvated ubiquitin.

Authors: Stormy L Koeniger; Samuel I Merenbloom; Sundarapandian Sevugarajan; David E Clemmer
Journal: J Am Chem Soc Date: 2006-09-06 Impact factor: 15.419

4. Solvent-free MALDI-MS for the analysis of beta-amyloid peptides via the mini-ball mill approach: qualitative and quantitative advances.

Authors: Sarah Trimpin; Max L Deinzer
Journal: J Am Soc Mass Spectrom Date: 2007-04-29 Impact factor: 3.109

Review 5. Analysis of insoluble proteins.

Authors: Sarah Trimpin; Bill Brizzard
Journal: Biotechniques Date: 2009-05 Impact factor: 1.993

6. Matrix-assisted laser desorption/ionization mass spectrometry method for selectively producing either singly or multiply charged molecular ions.

Authors: Sarah Trimpin; Ellen D Inutan; Thushani N Herath; Charles N McEwen
Journal: Anal Chem Date: 2010-01-01 Impact factor: 6.986

7. Resolution and structural transitions of elongated states of ubiquitin.

Authors: Stormy L Koeniger; David E Clemmer
Journal: J Am Soc Mass Spectrom Date: 2006-11-02 Impact factor: 3.109

8. Mapping the human plasma proteome by SCX-LC-IMS-MS.

Authors: Xiaoyun Liu; Stephen J Valentine; Manolo D Plasencia; Sarah Trimpin; Stephen Naylor; David E Clemmer
Journal: J Am Soc Mass Spectrom Date: 2007-04-24 Impact factor: 3.109

9. Ion mobility spectrometry/mass spectrometry snapshots for assessing the molecular compositions of complex polymeric systems.

Authors: Sarah Trimpin; David E Clemmer
Journal: Anal Chem Date: 2008-12-01 Impact factor: 6.986

10. Laserspray ionization, a new atmospheric pressure MALDI method for producing highly charged gas-phase ions of peptides and proteins directly from solid solutions.

Authors: Sarah Trimpin; Ellen D Inutan; Thushani N Herath; Charles N McEwen
Journal: Mol Cell Proteomics Date: 2009-11-13 Impact factor: 5.911

12 in total

1. A new approach to high sensitivity liquid chromatography-mass spectrometry of peptides using nanoflow solvent assisted inlet ionization.

Authors: Beixi Wang; Ellen D Inutan; Sarah Trimpin
Journal: J Am Soc Mass Spectrom Date: 2012-01-12 Impact factor: 3.109

2. Laserspray ionization using an atmospheric solids analysis probe for sample introduction.

Authors: Frank Zydel; Sarah Trimpin; Charles N McEwen
Journal: J Am Soc Mass Spectrom Date: 2010-07-22 Impact factor: 3.109

3. Matrix assisted ionization: new aromatic and nonaromatic matrix compounds producing multiply charged lipid, peptide, and protein ions in the positive and negative mode observed directly from surfaces.

Authors: Jing Li; Ellen D Inutan; Beixi Wang; Christopher B Lietz; Daniel R Green; Cory D Manly; Alicia L Richards; Darrell D Marshall; Steven Lingenfelter; Yue Ren; Sarah Trimpin
Journal: J Am Soc Mass Spectrom Date: 2012-08-16 Impact factor: 3.109

4. Spontaneous Charge Separation and Sublimation Processes are Ubiquitous in Nature and in Ionization Processes in Mass Spectrometry.

Authors: Sarah Trimpin; I-Chung Lu; Stephan Rauschenbach; Khoa Hoang; Beixi Wang; Nicholas D Chubatyi; Wen-Jing Zhang; Ellen D Inutan; Milan Pophristic; Alexander Sidorenko; Charles N McEwen
Journal: J Am Soc Mass Spectrom Date: 2017-10-27 Impact factor: 3.109

5. A mechanism for ionization of nonvolatile compounds in mass spectrometry: considerations from MALDI and inlet ionization.

Authors: Sarah Trimpin; Beixi Wang; Ellen D Inutan; Jing Li; Christopher B Lietz; Andrew Harron; Vincent S Pagnotti; Diana Sardelis; Charles N McEwen
Journal: J Am Soc Mass Spectrom Date: 2012-07-12 Impact factor: 3.109

10. Laserspray ionization, a new method for protein analysis directly from tissue at atmospheric pressure with ultrahigh mass resolution and electron transfer dissociation.

Authors: Ellen D Inutan; Alicia L Richards; James Wager-Miller; Ken Mackie; Charles N McEwen; Sarah Trimpin
Journal: Mol Cell Proteomics Date: 2010-09-20 Impact factor: 5.911