Literature DB >> 20435402

A revisit to the one form kinetic model of prothrombinase.

Chang Jun Lee1, Sangwook Wu, Changsun Eun, Lee G Pedersen.   

Abstract

Thrombin is generated enzymatically from prothrombin by two pathways with the intermediates of meizothrombin and prethrombin-2. Experimental concentration profiles from two independent groups for these two pathways have been re-analyzed. By rationally combining the independent data sets, a simple mechanism can be established and rate constants determined. A structural model is consistent with the data-derived finding that mechanisms that feature channeling or ratcheting are not necessary to describe thrombin production. 2010 Elsevier B.V. All rights reserved.

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Year:  2010        PMID： 20435402      PMCID： PMC2877601          DOI： 10.1016/j.bpc.2010.03.011

Source DB:  PubMed          Journal:  Biophys Chem        ISSN： 0301-4622            Impact factor:   2.352


  19 in total

Review 1.  Exosite-driven substrate specificity and function in coagulation.

Authors:  S Krishnaswamy
Journal:  J Thromb Haemost       Date:  2005-01       Impact factor: 5.824

2.  Ratcheting of the substrate from the zymogen to proteinase conformations directs the sequential cleavage of prothrombin by prothrombinase.

Authors:  Elsa P Bianchini; Steven J Orcutt; Peter Panizzi; Paul E Bock; Sriram Krishnaswamy
Journal:  Proc Natl Acad Sci U S A       Date:  2005-07-08       Impact factor: 11.205

3.  New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.

Authors:  P D Martin; M G Malkowski; J Box; C T Esmon; B F Edwards
Journal:  Structure       Date:  1997-12-15       Impact factor: 5.006

4.  Comparative protein modelling by satisfaction of spatial restraints.

Authors:  A Sali; T L Blundell
Journal:  J Mol Biol       Date:  1993-12-05       Impact factor: 5.469

5.  The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.

Authors:  M E Nesheim; J B Taswell; K G Mann
Journal:  J Biol Chem       Date:  1979-11-10       Impact factor: 5.157

6.  Binding of substrate in two conformations to human prothrombinase drives consecutive cleavage at two sites in prothrombin.

Authors:  Steven J Orcutt; Sriram Krishnaswamy
Journal:  J Biol Chem       Date:  2004-10-19       Impact factor: 5.157

7.  The activation of prothrombin by the prothrombinase complex. The contribution of the substrate-membrane interaction to catalysis.

Authors:  R K Walker; S Krishnaswamy
Journal:  J Biol Chem       Date:  1994-11-04       Impact factor: 5.157

8.  The conversion of prothrombin to thrombin. I. Characterization of the reaction products formed during the activation of bovine prothrombin.

Authors:  W G Owen; C T Esmon; C M Jackson
Journal:  J Biol Chem       Date:  1974-01-25       Impact factor: 5.157

9.  Activation of human prothrombin by human prothrombinase. Influence of factor Va on the reaction mechanism.

Authors:  S Krishnaswamy; W R Church; M E Nesheim; K G Mann
Journal:  J Biol Chem       Date:  1987-03-05       Impact factor: 5.157

10.  The prothrombinase-catalyzed activation of prothrombin proceeds through the intermediate meizothrombin in an ordered, sequential reaction.

Authors:  S Krishnaswamy; K G Mann; M E Nesheim
Journal:  J Biol Chem       Date:  1986-07-05       Impact factor: 5.157
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  12 in total

1.  Crystal structure of prethrombin-1.

Authors:  Zhiwei Chen; Leslie A Pelc; Enrico Di Cera
Journal:  Proc Natl Acad Sci U S A       Date:  2010-10-25       Impact factor: 11.205

Review 2.  The transition of prothrombin to thrombin.

Authors:  S Krishnaswamy
Journal:  J Thromb Haemost       Date:  2013-06       Impact factor: 5.824

3.  Meizothrombin is an unexpectedly zymogen-like variant of thrombin.

Authors:  Harlan N Bradford; Sriram Krishnaswamy
Journal:  J Biol Chem       Date:  2012-07-19       Impact factor: 5.157

4.  Evidence of the E*-E equilibrium from rapid kinetics of Na+ binding to activated protein C and factor Xa.

Authors:  Austin D Vogt; Alaji Bah; Enrico Di Cera
Journal:  J Phys Chem B       Date:  2010-09-02       Impact factor: 2.991

5.  Prothrombin structure: unanticipated features and opportunities.

Authors:  Nicola Pozzi; Enrico Di Cera
Journal:  Expert Rev Proteomics       Date:  2014-10-18       Impact factor: 3.940

6.  Prothrombin activation by platelet-associated prothrombinase proceeds through the prethrombin-2 pathway via a concerted mechanism.

Authors:  Laura M Haynes; Beth A Bouchard; Paula B Tracy; Kenneth G Mann
Journal:  J Biol Chem       Date:  2012-09-18       Impact factor: 5.157

7.  The linker connecting the two kringles plays a key role in prothrombin activation.

Authors:  Nicola Pozzi; Zhiwei Chen; Leslie A Pelc; Daniel B Shropshire; Enrico Di Cera
Journal:  Proc Natl Acad Sci U S A       Date:  2014-05-12       Impact factor: 11.205

8.  How the Linker Connecting the Two Kringles Influences Activation and Conformational Plasticity of Prothrombin.

Authors:  Nicola Pozzi; Zhiwei Chen; Enrico Di Cera
Journal:  J Biol Chem       Date:  2016-01-12       Impact factor: 5.157

9.  Membrane binding by prothrombin mediates its constrained presentation to prothrombinase for cleavage.

Authors:  Harlan N Bradford; Steven J Orcutt; Sriram Krishnaswamy
Journal:  J Biol Chem       Date:  2013-08-12       Impact factor: 5.157

10.  Expression and characterization of recombinant ecarin.

Authors:  Anna Jonebring; Ute Lange; Elke Bucha; Johanna Deinum; Margareta Elg; Ann Lövgren
Journal:  Protein J       Date:  2012-06       Impact factor: 2.371
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