Literature DB >> 20435300

Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives.

David Soriano del Amo1, Wei Wang, Christen Besanceney, Tianqing Zheng, Yizheng He, Brian Gerwe, Ronald D Seidel, Peng Wu.   

Abstract

A combination of recombinant FKP and alpha-(1-->3)-fucosyltransferase allows the facile synthesis of the sialyl Lewis X tetrasaccharide glycan and its derivatives in excellent yield. In this system, the universal fucosyl donor, guanidine 5'-diphosphate-beta-L-fucose (GDP-fucose), or its analogues can be generated in situ by cofactor recycling using pyruvate kinase. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20435300      PMCID: PMC2945603          DOI: 10.1016/j.carres.2010.03.032

Source DB:  PubMed          Journal:  Carbohydr Res        ISSN: 0008-6215            Impact factor:   2.104


  23 in total

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4.  Structure--activity relationships of sialyl Lewis x-containing oligosaccharides. 1. Effect of modifications of the fucose moiety.

Authors:  J Y Ramphal; Z L Zheng; C Perez; L E Walker; S A DeFrees; F C Gaeta
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6.  Human symbionts use a host-like pathway for surface fucosylation.

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7.  Regeneration of sugar nucleotide for enzymatic oligosaccharide synthesis.

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Journal:  Methods Enzymol       Date:  1994       Impact factor: 1.600

8.  ELAM-1 mediates cell adhesion by recognition of a carbohydrate ligand, sialyl-Lex.

Authors:  M L Phillips; E Nudelman; F C Gaeta; M Perez; A K Singhal; S Hakomori; J C Paulson
Journal:  Science       Date:  1990-11-23       Impact factor: 47.728

9.  Sialoside analogue arrays for rapid identification of high affinity siglec ligands.

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Review 10.  Opportunities and challenges in synthetic oligosaccharide and glycoconjugate research.

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Journal:  Nat Chem       Date:  2009-11       Impact factor: 24.427

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  7 in total

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3.  Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation.

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5.  Cell-based glycan arrays for probing glycan-glycan binding protein interactions.

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Review 6.  Bioisosteres of Carbohydrate Functional Groups in Glycomimetic Design.

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7.  A Single-Step Chemoenzymatic Reaction for the Construction of Antibody-Cell Conjugates.

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  7 in total

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