Literature DB >> 20433165

The effect of charge-reversal amphiphile spacer composition on DNA and siRNA delivery.

Xiao-Xiang Zhang1, Carla A H Prata, Thomas J McIntosh, Philippe Barthélémy, Mark W Grinstaff.   

Abstract

A series of charge-reversal amphiphiles with different spacers separating the headgroup from the hydrophobic chains are described for delivery of DNA and siRNA. Among them, the amphiphiles possessing a glycine spacer (e.g., B-GlyGly) showed effective DNA transfection in CHO and NIH 3T3 cells, as well as siRNA gene knockdown in HepG2 and UASMC cells. Ethidium bromide quenching assays revealed that DNA was released the fastest from the lipoplex of B-GlyGly in the presence of esterase. Also, X-ray diffraction results indicated that the DNA was located between the adjacent lipid bilayers in the lipoplex of B-GlyGly. These distinct features appear to be required for high transfection activity.

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Year:  2010        PMID： 20433165      PMCID： PMC3052776          DOI： 10.1021/bc9005464

Source DB:  PubMed          Journal:  Bioconjug Chem        ISSN： 1043-1802            Impact factor:   4.774


  40 in total

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