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Literature DB >> 21621581

Functional lipids and lipoplexes for improved gene delivery.

Xiao-Xiang Zhang¹, Thomas J McIntosh, Mark W Grinstaff.

Abstract

Cationic lipids are the most common non-viral vectors used in gene delivery with a few currently being investigated in clinical trials. However, like most other synthetic vectors, these vectors suffer from low transfection efficiencies. Among the various approaches to address this challenge, functional lipids (i.e., lipids responding to a stimuli) offer a myriad of opportunities for basic studies of nucleic acid-lipid interactions and for in vitro and in vivo delivery of nucleic acid for a specific biological/medical application. This manuscript reviews recent advances in pH, redox, and charge-reversal sensitive lipids.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Cations
Lipids

Year: 2011 PMID： 21621581 PMCID： PMC3771368 DOI： 10.1016/j.biochi.2011.05.005

Source DB: PubMed Journal: Biochimie ISSN： 0300-9084 Impact factor: 4.079

170 in total

1. Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration.

Authors: M Ouyang; J S Remy; F C Szoka
Journal: Bioconjug Chem Date: 2000 Jan-Feb Impact factor: 4.774

Review 2. Cationic liposome-mediated gene transfer.

Authors: X Gao; L Huang
Journal: Gene Ther Date: 1995-12 Impact factor: 5.250

3. Physical and biological properties of cationic triesters of phosphatidylcholine.

Authors: R C MacDonald; G W Ashley; M M Shida; V A Rakhmanova; Y S Tarahovsky; D P Pantazatos; M T Kennedy; E V Pozharski; K A Baker; R D Jones; H S Rosenzweig; K L Choi; R Qiu; T J McIntosh
Journal: Biophys J Date: 1999-11 Impact factor: 4.033

4. High-efficiency gene transfer into skeletal muscle mediated by electric pulses.

Authors: L M Mir; M F Bureau; J Gehl; R Rangara; D Rouy; J M Caillaud; P Delaere; D Branellec; B Schwartz; D Scherman
Journal: Proc Natl Acad Sci U S A Date: 1999-04-13 Impact factor: 11.205

5. A novel cationic lipophosphoramide with diunsaturated lipid chains: synthesis, physicochemical properties, and transfection activities.

Authors: Tony Le Gall; Damien Loizeau; Erwan Picquet; Nathalie Carmoy; Jean-Jacques Yaouanc; Laure Burel-Deschamps; Pascal Delépine; Philippe Giamarchi; Paul-Alain Jaffrès; Pierre Lehn; Tristan Montier
Journal: J Med Chem Date: 2010-02-25 Impact factor: 7.446

6. Acid-catalyzed plasmenylcholine hydrolysis and its effect on bilayer permeability: a quantitative study.

Authors: O V Gerasimov; A Schwan; D H Thompson
Journal: Biochim Biophys Acta Date: 1997-03-13

7. Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis.

Authors: Inge S Zuhorn; Ruby Kalicharan; Dick Hoekstra
Journal: J Biol Chem Date: 2002-03-01 Impact factor: 5.157

8. Cellular and molecular barriers to gene transfer by a cationic lipid.

Authors: J Zabner; A J Fasbender; T Moninger; K A Poellinger; M J Welsh
Journal: J Biol Chem Date: 1995-08-11 Impact factor: 5.157

9. Entrapment of a bacterial plasmid in phospholipid vesicles: potential for gene transfer.

Authors: R T Fraley; C S Fornari; S Kaplan
Journal: Proc Natl Acad Sci U S A Date: 1979-07 Impact factor: 11.205

10. Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum.

Authors: S Capaccioli; G Di Pasquale; E Mini; T Mazzei; A Quattrone
Journal: Biochem Biophys Res Commun Date: 1993-12-15 Impact factor: 3.575

27 in total

Functional lipids and lipoplexes for improved gene delivery.

1. Controlled template-assisted assembly of plasmid DNA into nanometric particles with high DNA concentration.

Review 2. Cationic liposome-mediated gene transfer.

3. Physical and biological properties of cationic triesters of phosphatidylcholine.

4. High-efficiency gene transfer into skeletal muscle mediated by electric pulses.

5. A novel cationic lipophosphoramide with diunsaturated lipid chains: synthesis, physicochemical properties, and transfection activities.

6. Acid-catalyzed plasmenylcholine hydrolysis and its effect on bilayer permeability: a quantitative study.

7. Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis.

8. Cellular and molecular barriers to gene transfer by a cationic lipid.

9. Entrapment of a bacterial plasmid in phospholipid vesicles: potential for gene transfer.

10. Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum.

Review 1. Improving Molecular Therapy in the Kidney.

2. Inorganic nanovectors for nucleic acid delivery.

3. Nanomedicine for gene therapy.

Review 4. Transfection by cationic gemini lipids and surfactants.

Review 5. Drug delivery systems, CNS protection, and the blood brain barrier.

6. Charge-reversal lipids, peptide-based lipids, and nucleoside-based lipids for gene delivery.

7. Lipid-mediated DNA and siRNA Transfection Efficiency Depends on Peptide Headgroup.

8. Design and evaluation of new pH-sensitive amphiphilic cationic lipids for siRNA delivery.

9. Spatial control of cell transfection using soluble or solid-phase redox agents and a redox-active ferrocenyl lipid.

10. Targeted Delivery of Doxorubicin Liposomes for Her-2+ Breast Cancer Treatment.