AIMS: To evaluate bone turnover in children with type 1 diabetes mellitus (DM1) at onset, after 3 and 12 months of treatment, and in children with longer duration of disease, and its association with glycemic control. PATIENTS AND METHODS: 17 children with DM1 at onset, 30 with DM1 of longer duration and 45 controls participated in the study. Tartrate-resistant acid phosphatase 5b (TRACP5b), crosslinked C-terminal telopeptides of type I collagen (CTX) and osteocalcin (OC) were assessed. RESULTS: At onset of DM1 osteocalcin (p < 0.0003) and log CTX (p < 0.003) were lower than in controls but returned to reference levels after 3 months of therapy. TRACP5b in children with DM1 increased gradually and after 12 months was higher than at onset (p < 0.03). OC at onset inversely correlated with HbA1c (r = -0.40, p = 0.03). In children with DM1 of longer duration and HbA1c > 6.5%, sex-dependent differences were found in OC and CTX. Girls with HbA1 > 6.5% had lower OC and CTX than controls (p < 0.005, p < 0.003). Inverse correlations were found between HbA1c and OC and CTX (r = -0.50, p = 0.04; r = -0.49, p = 0.03). CONCLUSIONS: Proper glycemic control has a beneficial influence on bone turnover, which may prevent low bone mass in adulthood.
AIMS: To evaluate bone turnover in children with type 1 diabetes mellitus (DM1) at onset, after 3 and 12 months of treatment, and in children with longer duration of disease, and its association with glycemic control. PATIENTS AND METHODS: 17 children with DM1 at onset, 30 with DM1 of longer duration and 45 controls participated in the study. Tartrate-resistant acid phosphatase 5b (TRACP5b), crosslinked C-terminal telopeptides of type I collagen (CTX) and osteocalcin (OC) were assessed. RESULTS: At onset of DM1osteocalcin (p < 0.0003) and log CTX (p < 0.003) were lower than in controls but returned to reference levels after 3 months of therapy. TRACP5b in children with DM1 increased gradually and after 12 months was higher than at onset (p < 0.03). OC at onset inversely correlated with HbA1c (r = -0.40, p = 0.03). In children with DM1 of longer duration and HbA1c > 6.5%, sex-dependent differences were found in OC and CTX. Girls with HbA1 > 6.5% had lower OC and CTX than controls (p < 0.005, p < 0.003). Inverse correlations were found between HbA1c and OC and CTX (r = -0.50, p = 0.04; r = -0.49, p = 0.03). CONCLUSIONS: Proper glycemic control has a beneficial influence on bone turnover, which may prevent low bone mass in adulthood.
Authors: J P R O Orgel; O Antipova; I Sagi; A Bitler; D Qiu; R Wang; Y Xu; J D San Antonio Journal: Connect Tissue Res Date: 2010-11-30 Impact factor: 3.417
Authors: C Tsentidis; D Gourgiotis; L Kossiva; A Doulgeraki; A Marmarinos; A Galli-Tsinopoulou; K Karavanaki Journal: Osteoporos Int Date: 2015-11-20 Impact factor: 4.507