PURPOSE: To develop a fully quantitative 4D transcatheter intraarterial perfusion (TRIP) magnetic resonance imaging (MRI) technique and prospectively test the hypothesis that quantitative 4D TRIP-MRI can be used clinically to monitor intraprocedural liver tumor perfusion reductions during transcatheter arterial chemoembolization (TACE). MATERIALS AND METHODS: TACE was performed within an x-ray digital subtraction angiography (DSA)-MRI procedure suite in 16 patients with hepatocellular carcinoma. Quantitative 4D TRIP-MRI with targeted radiofrequency field mapping and dynamic longitudinal relaxation rate mapping was used to monitor changes in tumor perfusion during TACE. First-pass perfusion analysis was performed to produce intraprocedural blood flow (Frho) maps. Mean liver tumor perfusions before and after TACE were compared with a paired t-test (alpha = 0.05). RESULTS: Perfusion reductions were successfully measured with quantitative 4D TRIP-MRI in 22 separate tumors during 18 treatment sessions. Mean tumor perfusion Frho decreased from 16.3 (95% confidence interval [CI]: 10.7-21.9) before TACE to 5.0 (95% CI: 3.5-6.5) (mL/min/100 mL) after TACE. Tumor perfusion reductions were statistically significant (P < 0.0005), with a mean absolute perfusion change of 11.4 (95% CI: 5.6-17.1) (mL/min/100 mL) and a mean percentage reduction of 61.0% (95% CI: 48.3%-73.6%). CONCLUSION: Quantitative 4D TRIP-MRI can be successfully performed within clinical interventional settings to monitor intraprocedural changes in liver tumor perfusion during TACE. Copyright 2010 Wiley-Liss, Inc.
PURPOSE: To develop a fully quantitative 4D transcatheter intraarterial perfusion (TRIP) magnetic resonance imaging (MRI) technique and prospectively test the hypothesis that quantitative 4D TRIP-MRI can be used clinically to monitor intraprocedural liver tumor perfusion reductions during transcatheter arterial chemoembolization (TACE). MATERIALS AND METHODS:TACE was performed within an x-ray digital subtraction angiography (DSA)-MRI procedure suite in 16 patients with hepatocellular carcinoma. Quantitative 4D TRIP-MRI with targeted radiofrequency field mapping and dynamic longitudinal relaxation rate mapping was used to monitor changes in tumor perfusion during TACE. First-pass perfusion analysis was performed to produce intraprocedural blood flow (Frho) maps. Mean liver tumor perfusions before and after TACE were compared with a paired t-test (alpha = 0.05). RESULTS: Perfusion reductions were successfully measured with quantitative 4D TRIP-MRI in 22 separate tumors during 18 treatment sessions. Mean tumor perfusion Frho decreased from 16.3 (95% confidence interval [CI]: 10.7-21.9) before TACE to 5.0 (95% CI: 3.5-6.5) (mL/min/100 mL) after TACE. Tumor perfusion reductions were statistically significant (P < 0.0005), with a mean absolute perfusion change of 11.4 (95% CI: 5.6-17.1) (mL/min/100 mL) and a mean percentage reduction of 61.0% (95% CI: 48.3%-73.6%). CONCLUSION: Quantitative 4D TRIP-MRI can be successfully performed within clinical interventional settings to monitor intraprocedural changes in liver tumor perfusion during TACE. Copyright 2010 Wiley-Liss, Inc.
Authors: Andrew C Larson; Thomas K Rhee; Jie Deng; Dingxin Wang; Kent T Sato; Riad Salem; Tatjana Paunesku; Gayle Woloschak; Mary F Mulcahy; Debiao Li; Reed A Omary Journal: J Magn Reson Imaging Date: 2006-07 Impact factor: 4.813
Authors: Daniel B Brown; John F Cardella; David Sacks; S Nahum Goldberg; Debra A Gervais; Dheeraj Rajan; Suresh Vedantham; Donald L Miller; Elias N Brountzos; Clement J Grassi; Richard B Towbin Journal: J Vasc Interv Radiol Date: 2006-02 Impact factor: 3.464
Authors: P S Tofts; G Brix; D L Buckley; J L Evelhoch; E Henderson; M V Knopp; H B Larsson; T Y Lee; N A Mayr; G J Parker; R E Port; J Taylor; R M Weisskoff Journal: J Magn Reson Imaging Date: 1999-09 Impact factor: 4.813
Authors: Qiong Huang; Xingbin Hu; Wanming He; Yang Zhao; Shihui Hao; Qijing Wu; Shaowei Li; Shuyi Zhang; Min Shi Journal: Am J Cancer Res Date: 2018-05-01 Impact factor: 6.166
Authors: Xiaoming Yin; Yang Guo; Weiguo Li; Eugene Huo; Zhuoli Zhang; Jodi Nicolai; Robert A Kleps; Diego Hernando; Aggelos K Katsaggelos; Reed A Omary; Andrew C Larson Journal: Radiology Date: 2012-06 Impact factor: 11.105
Authors: Dingxin Wang; Ron C Gaba; Brian Jin; Ahsun Riaz; Robert J Lewandowski; Robert K Ryu; Kent T Sato; Ann B Ragin; Laura M Kulik; Mary F Mulcahy; Riad Salem; Andrew C Larson; Reed A Omary Journal: Acad Radiol Date: 2011-07 Impact factor: 3.173
Authors: Dingxin Wang; Ron C Gaba; Brian Jin; Robert J Lewandowski; Ahsun Riaz; Khairuddin Memon; Robert K Ryu; Kent T Sato; Laura M Kulik; Mary F Mulcahy; Andrew C Larson; Riad Salem; Reed A Omary Journal: Radiology Date: 2014-03-28 Impact factor: 11.105
Authors: Brian Jin; Dingxin Wang; Robert J Lewandowski; Ahsun Riaz; Robert K Ryu; Kent T Sato; Andrew C Larson; Riad Salem; Reed A Omary Journal: AJR Am J Roentgenol Date: 2011-04 Impact factor: 3.959
Authors: Brian Jin; Dingxin Wang; Robert J Lewandowski; Robert K Ryu; Kent T Sato; Andrew C Larson; Riad Salem; Reed A Omary Journal: AJR Am J Roentgenol Date: 2011-11 Impact factor: 3.959
Authors: Carmen Gacchina Johnson; Karun V Sharma; Elliot B Levy; David L Woods; Aaron H Morris; John D Bacher; Andrew L Lewis; Bradford J Wood; Matthew R Dreher Journal: J Vasc Interv Radiol Date: 2015-08-28 Impact factor: 3.464
Authors: Grzegorz Staśkiewicz; Kamil Torres; Marta Denisow; Anna Torres; Elżbieta Czekajska-Chehab; Andrzej Drop Journal: Surg Radiol Anat Date: 2015-05-17 Impact factor: 1.246