Literature DB >> 20431697

Mechanisms and inhibition of HIV integration.

Christophe Marchand1, Allison A Johnson, Elena Semenova, Yves Pommier.   

Abstract

HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described.

Year:  2006        PMID： 20431697      PMCID： PMC2860614          DOI： 10.1016/j.ddmec.2006.05.004

Source DB:  PubMed          Journal:  Drug Discov Today Dis Mech        ISSN： 1740-6765


  52 in total

1.  Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway.

Authors:  Naoto Yoshizuka; Yuko Yoshizuka-Chadani; Vyjayanthi Krishnan; Steven L Zeichner
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

2.  During the early phase of HIV-1 DNA synthesis, nucleocapsid protein directs hybridization of the TAR complementary sequences via the ends of their double-stranded stem.

Authors:  Julien Godet; Hugues de Rocquigny; Chinnappan Raja; Nicole Glasser; Damien Ficheux; Jean-Luc Darlix; Yves Mély
Journal:  J Mol Biol       Date:  2005-12-27       Impact factor: 5.469

3.  Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus.

Authors:  Linos Vandekerckhove; Frauke Christ; Bénédicte Van Maele; Jan De Rijck; Rik Gijsbers; Chris Van den Haute; Myriam Witvrouw; Zeger Debyser
Journal:  J Virol       Date:  2006-02       Impact factor: 5.103

4.  Retrovirus meeting. Novel attacks on HIV move closer to reality.

Authors:  Jon Cohen
Journal:  Science       Date:  2006-02-17       Impact factor: 47.728

5.  Functional interactions of human immunodeficiency virus type 1 integrase with human and yeast HSP60.

Authors:  V Parissi; C Calmels; V R De Soultrait; A Caumont; M Fournier; S Chaignepain; S Litvak
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

6.  Acetylation of HIV-1 integrase by p300 regulates viral integration.

Authors:  Anna Cereseto; Lara Manganaro; Maria Ines Gutierrez; Mariaelena Terreni; Antonio Fittipaldi; Marina Lusic; Alessandro Marcello; Mauro Giacca
Journal:  EMBO J       Date:  2005-08-11       Impact factor: 11.598

Review 7.  A hard way to the nucleus.

Authors:  Michael Bukrinsky
Journal:  Mol Med       Date:  2004 Jan-Jun       Impact factor: 6.354

8.  The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes.

Authors:  Chou-Wen Lin; Alan Engelman
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

Review 9.  Cellular co-factors of HIV-1 integration.

Authors:  Bénédicte Van Maele; Katrien Busschots; Linos Vandekerckhove; Frauke Christ; Zeger Debyser
Journal:  Trends Biochem Sci       Date:  2006-01-05       Impact factor: 13.807

10.  Complex interactions of HIV-1 nucleocapsid protein with oligonucleotides.

Authors:  Robert J Fisher; Matthew J Fivash; Andrew G Stephen; Nathan A Hagan; Shilpa R Shenoy; Maxine V Medaglia; Lindsey R Smith; Karen M Worthy; John T Simpson; Robert Shoemaker; Karen L McNitt; Donald G Johnson; Catherine V Hixson; Robert J Gorelick; Daniele Fabris; Louis E Henderson; Alan Rein
Journal:  Nucleic Acids Res       Date:  2006-01-24       Impact factor: 16.971
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  8 in total

1.  Synthesis and HIV-1 integrase inhibitory activity of spiroundecane(ene) derivatives.

Authors:  Elvira E Shults; Elena A Semenova; Allison A Johnson; Svetlana P Bondarenko; Irina Y Bagryanskaya; Yuri V Gatilov; Genrikh A Tolstikov; Yves Pommier
Journal:  Bioorg Med Chem Lett       Date:  2006-12-03       Impact factor: 2.823

2.  The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms.

Authors:  Kimberly Walker; Divya Kalra; Rebecca Lowdon; Guangyi Chen; David Molik; Daniela C Soto; Fawaz Dabbaghie; Ahmad Al Khleifat; Medhat Mahmoud; Luis F Paulin; Muhammad Sohail Raza; Susanne P Pfeifer; Daniel Paiva Agustinho; Elbay Aliyev; Pavel Avdeyev; Enrico R Barrozo; Sairam Behera; Kimberley Billingsley; Li Chuin Chong; Deepak Choubey; Wouter De Coster; Yilei Fu; Alejandro R Gener; Timothy Hefferon; David Morgan Henke; Wolfram Höps; Anastasia Illarionova; Michael D Jochum; Maria Jose; Rupesh K Kesharwani; Sree Rohit Raj Kolora; Jędrzej Kubica; Priya Lakra; Damaris Lattimer; Chia-Sin Liew; Bai-Wei Lo; Chunhsuan Lo; Anneri Lötter; Sina Majidian; Suresh Kumar Mendem; Rajarshi Mondal; Hiroko Ohmiya; Nasrin Parvin; Carolina Peralta; Chi-Lam Poon; Ramanandan Prabhakaran; Marie Saitou; Aditi Sammi; Philippe Sanio; Nicolae Sapoval; Najeeb Syed; Todd Treangen; Gaojianyong Wang; Tiancheng Xu; Jianzhi Yang; Shangzhe Zhang; Weiyu Zhou; Fritz J Sedlazeck; Ben Busby
Journal:  F1000Res       Date:  2022-05-16

Review 3.  HIV-1 IN inhibitors: 2010 update and perspectives.

Authors:  Christophe Marchand; Kasthuraiah Maddali; Mathieu Métifiot; Yves Pommier
Journal:  Curr Top Med Chem       Date:  2009       Impact factor: 3.295

4.  Covalent binding of the natural antimicrobial peptide indolicidin to DNA abasic sites.

Authors:  Christophe Marchand; Krzysztof Krajewski; Hsiu-Fang Lee; Smitha Antony; Allison A Johnson; Ronak Amin; Peter Roller; Mamuka Kvaratskhelia; Yves Pommier
Journal:  Nucleic Acids Res       Date:  2006-09-22       Impact factor: 16.971

Review 5.  HIV-1 latency in monocytes/macrophages.

Authors:  Amit Kumar; Wasim Abbas; Georges Herbein
Journal:  Viruses       Date:  2014-04-22       Impact factor: 5.048

6.  A Combination of M50I and V151I Polymorphic Mutations in HIV-1 Subtype B Integrase Results in Defects in Autoprocessing.

Authors:  Jun Yang; Ming Hao; Muhammad A Khan; Muhammad T Rehman; Helene C Highbarger; Qian Chen; Suranjana Goswami; Brad T Sherman; Catherine A Rehm; Robin L Dewar; Weizhong Chang; Tomozumi Imamichi
Journal:  Viruses       Date:  2021-11-22       Impact factor: 5.048

7.  Characterization of the Role of Host Cellular Factor Histone Deacetylase 10 during HIV-1 Replication.

Authors:  Xiaozhuo Ran; Zhujun Ao; Titus Olukitibi; Xiaojian Yao
Journal:  Viruses       Date:  2019-12-26       Impact factor: 5.048

8.  Conditionally Replicating Vectors Mobilize Chimeric Antigen Receptors against HIV.

Authors:  Ryan Z Urak; Citradewi Soemardy; Roslyn Ray; Shirley Li; Galina Shevchenko; Tristan Scott; Laura Lim; Xiuli Wang; Kevin V Morris
Journal:  Mol Ther Methods Clin Dev       Date:  2020-09-28       Impact factor: 6.698
  8 in total

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