Literature DB >> 204298

Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase.

P H Sugden, N J Hutson, A L Kerbey, P J Randle.   

Abstract

The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.

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Year:  1978        PMID： 204298      PMCID： PMC1184185          DOI： 10.1042/bj1690433

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Emergency medicine.

Authors:  I J Cohen
Journal:  J Med Assoc State Ala       Date:  1976-04

2.  Peptides derived from pyruvate dehydrogenase as substrates for pyruvate dehydrogenase kinase and phosphatase.

Authors:  P F Davis; F H Pettit; L J Reed
Journal:  Biochem Biophys Res Commun       Date:  1977-04-11       Impact factor: 3.575

3.  Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase.

Authors:  R M Denton; P J Randle; B R Martin
Journal:  Biochem J       Date:  1972-06       Impact factor: 3.857

4.  Assay of cyclic AMP-dependent protein kinases.

Authors:  J D Corbin; E M Reimann
Journal:  Methods Enzymol       Date:  1974       Impact factor: 1.600

5.  Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion.

Authors:  O Wieland; E Siess; F H Schulze-Wethmar; H G von Funcke; B Winton
Journal:  Arch Biochem Biophys       Date:  1971-04       Impact factor: 4.013

6.  Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation.

Authors:  T C Linn; F H Pettit; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1969-01       Impact factor: 11.205

7.  Regulation of heart muscle pyruvate dehydrogenase kinase.

Authors:  R H Cooper; P J Randle; R M Denton
Journal:  Biochem J       Date:  1974-12       Impact factor: 3.857

8.  Diabetes and the control of pyruvate dehydrogenase in rat heart mitochondria by concentration ratios of adenosine triphosphate/adenosine diphosphate, of reduced/oxidized nicotinamide-adenine dinucleotide and of acetyl-coenzyme A/coenzyme A.

Authors:  A L Kerbey; P M Radcliffe; P J Randle
Journal:  Biochem J       Date:  1977-06-15       Impact factor: 3.857

9.  Calcium and magnesium ions as effectors of adipose-tissue pyruvate dehydrogenase phosphate phosphatase.

Authors:  D L Severson; R M Denton; H T Pask; P J Randle
Journal:  Biochem J       Date:  1974-05       Impact factor: 3.857

10.  Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine dinucleotide.

Authors:  A L Kerbey; P J Randle; R H Cooper; S Whitehouse; H T Pask; R M Denton
Journal:  Biochem J       Date:  1976-02-15       Impact factor: 3.857
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  27 in total

Review 1.  Fuel selection and carbon flux during the starved-to-fed transition.

Authors:  M C Sugden; M J Holness; T N Palmer
Journal:  Biochem J       Date:  1989-10-15       Impact factor: 3.857

Review 2.  The 2-oxo acid dehydrogenase complexes: recent advances.

Authors:  S J Yeaman
Journal:  Biochem J       Date:  1989-02-01       Impact factor: 3.857

3.  Tissue-specific kinase expression and activity regulate flux through the pyruvate dehydrogenase complex.

Authors:  Alla Klyuyeva; Alina Tuganova; Natalia Kedishvili; Kirill M Popov
Journal:  J Biol Chem       Date:  2018-11-27       Impact factor: 5.157

4.  Conversion of inactive (phosphorylated) pyruvate dehydrogenase complex into active complex by the phosphate reaction in heart mitochondria is inhibited by alloxan-diabetes or starvation in the rat.

Authors:  N J Hutson; A L Kerbey; P J Randle; P H Sugden
Journal:  Biochem J       Date:  1978-08-01       Impact factor: 3.857

5.  Proportion of active dephosphorylated pyruvate dehydrogenase complex in heart and isolated heart mitochondria is decreased in obese hyperinsulinaemic mice.

Authors:  A L Kerbey; I D Caterson; P F Williams; J R Turtle
Journal:  Biochem J       Date:  1984-01-01       Impact factor: 3.857

6.  Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex.

Authors:  P H Sugden; A L Kerbey; P J Randle; C A Waller; K B Reid
Journal:  Biochem J       Date:  1979-08-01       Impact factor: 3.857

7.  Occupancy of phosphorylation sites in pyruvate dehydrogenase phosphate complex in rat heart in vivo. Relation to proportion of inactive complex and rate of re-activation by phosphatase.

Authors:  G J Sale; P J Randle
Journal:  Biochem J       Date:  1982-08-15       Impact factor: 3.857

8.  Hepatic glycogen synthesis on carbohydrate re-feeding after starvation. A regulatory role for pyruvate dehydrogenase in liver and extrahepatic tissues.

Authors:  M J Holness; T J French; M C Sugden
Journal:  Biochem J       Date:  1986-04-15       Impact factor: 3.857

9.  Regulation of pig heart pyruvate dehydrogenase by phosphorylation. Studies on the subunit and phosphorylation stoicheiometries.

Authors:  P H Sugden; P J Randle
Journal:  Biochem J       Date:  1978-08-01       Impact factor: 3.857

10.  Quantitative mitochondrial phosphoproteomics using iTRAQ on an LTQ-Orbitrap with high energy collision dissociation.

Authors:  Emily S Boja; Darci Phillips; Stephanie A French; Robert A Harris; Robert S Balaban
Journal:  J Proteome Res       Date:  2009-10       Impact factor: 4.466
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