Literature DB >> 6421278

Proportion of active dephosphorylated pyruvate dehydrogenase complex in heart and isolated heart mitochondria is decreased in obese hyperinsulinaemic mice.

A L Kerbey, I D Caterson, P F Williams, J R Turtle.   

Abstract

The proportion of active, dephosphorylated, pyruvate dehydrogenase complex was decreased in the mouse heart by obesity (by 56%), and this decrease in enzyme activity persisted during preparation and extraction of heart mitochondria. Phosphorylation and inactivation of pyruvate dehydrogenase may be a major factor in mediating the inhibitory effects of obesity on glucose oxidation in muscle, and this may represent an important mechanism in the development and/or expression of cellular insulin-resistance.

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Year:  1984        PMID： 6421278      PMCID： PMC1153188          DOI： 10.1042/bj2170117

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  17 in total

1.  Stimulation of phosphorylation and inactivation of pyruvate dehydrogenase by physiological inhibitors of the pyruvate dehydrogenase reaction.

Authors:  R H Cooper; P J Randle; R M Denton
Journal:  Nature       Date:  1975-10-30       Impact factor: 49.962

2.  Alpha-keto acid dehydrogenase complexes. XI. Comparative studies of regulatory properties of the pyruvate dehydrogenase complexes from kidney, heart, and liver mitochondria.

Authors:  T C Linn; F H Pettit; F Hucho; L J Reed
Journal:  Proc Natl Acad Sci U S A       Date:  1969-09       Impact factor: 11.205

3.  Thermolabile factor accelerates pyruvate dehydrogenase kinase reaction in heart mitochondria of starved or alloxan-diabetic rats.

Authors:  A L Kerbey; P J Randle
Journal:  FEBS Lett       Date:  1981-05-18       Impact factor: 4.124

Review 4.  Regulation of pyruvate oxidation and the conservation of glucose.

Authors:  P J Randle; P H Sugden; A L Kerbey; P M Radcliffe; N J Hutson
Journal:  Biochem Soc Symp       Date:  1978

5.  Islet cell function in gold thioglucose-induced obesity in mice.

Authors:  I D Caterson; K W Taylor
Journal:  Diabetologia       Date:  1982-08       Impact factor: 10.122

6.  Effect of the fatty acid oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in starved and alloxan-diabetic rats.

Authors:  I D Caterson; S J Fuller; P J Randle
Journal:  Biochem J       Date:  1982-10-15       Impact factor: 3.857

7.  Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids.

Authors:  S Whitehouse; R H Cooper; P J Randle
Journal:  Biochem J       Date:  1974-09       Impact factor: 3.857

8.  Occupancy of sites of phosphorylation in inactive rat heart pyruvate dehydrogenase phosphate in vivo.

Authors:  G J Sale; P J Randle
Journal:  Biochem J       Date:  1981-03-01       Impact factor: 3.857

9.  Pyruvate dehydrogenase kinase/activator in rat heart mitochondria, Assay, effect of starvation, and effect of protein-synthesis inhibitors of starvation.

Authors:  A L Kerbey; P J Randle
Journal:  Biochem J       Date:  1982-07-15       Impact factor: 3.857

10.  Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites.

Authors:  M Crettaz; M Prentki; D Zaninetti; B Jeanrenaud
Journal:  Biochem J       Date:  1980-02-15       Impact factor: 3.857
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  3 in total

1.  The activity of the pyruvate dehydrogenase complex in heart and liver from mice during the development of obesity and insulin resistance.

Authors:  I D Caterson; L D Astbury; P F Williams; M A Vanner; G J Cooney; J R Turtle
Journal:  Biochem J       Date:  1987-04-15       Impact factor: 3.857

2.  Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase.

Authors:  I D Caterson; A L Kerbey; G J Cooney; R Frankland; G S Denyer; J Nicks; P F Williams
Journal:  Biochem J       Date:  1988-07-01       Impact factor: 3.857

3.  The effect of body weight and the fatty acid-oxidation inhibitor 2-tetradecylglycidic acid on pyruvate dehydrogenase complex activity in mouse heart.

Authors:  I D Caterson; P F Williams; A L Kerbey; L D Astbury; W E Plehwe; J R Turtle
Journal:  Biochem J       Date:  1984-12-15       Impact factor: 3.857
  3 in total

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