BACKGROUND: Hantaviral antigens were originally reported more than 20 years ago in tissues of the Eurasian common shrew (Sorex araneus), captured in European and Siberian Russia. The recent discovery of Seewis virus (SWSV) in this soricid species in Switzerland provided an opportunity to investigate its genetic diversity and geographic distribution in Russia. METHODS: Lung tissues from 45 Eurasian common shrews, 4 Laxmann's shrews (Sorex caecutiens), 3 Siberian large-toothed shrews (Sorex daphaenodon), 9 pygmy shrews (Sorex minutus), 28 tundra shrews (Sorex tundrensis), and 6 Siberian shrews (Crocidura sibirica), captured in 11 localities in Western and Eastern Siberia during June 2007 to September 2008, were analyzed for hantavirus RNA by reverse transcription-polymerase chain reaction. RESULTS: Hantavirus L and S segment sequences, detected in 11 S. araneus, 2 S. tundrensis, and 2 S. daphaenodon, were closely related to SWSV, differing from the prototype mp70 strain by 16.3-20.2% at the nucleotide level and 1.4-1.7% at the amino acid level. Alignment and comparison of nucleotide and amino acid sequences showed an intrastrain difference of 0-11.0% and 0% for the L segment and 0.2-8.5% and 0% for the S segment, respectively. Phylogenetic analysis, using neighbor-joining, maximum-likelihood, and Bayesian methods, showed geographic-specific clustering of SWSV strains in Western and Eastern Siberia. CONCLUSIONS: This is the first definitive report of shrew-borne hantaviruses in Siberia, and demonstrates the impressive distribution of SWSV among phylogenetically related Sorex species. Coevolution and local adaptation of SWSV genetic variants in specific chromosomal races of S. araneus may account for their geographic distribution.
BACKGROUND: Hantaviral antigens were originally reported more than 20 years ago in tissues of the Eurasian common shrew (Sorex araneus), captured in European and Siberian Russia. The recent discovery of Seewis virus (SWSV) in this soricid species in Switzerland provided an opportunity to investigate its genetic diversity and geographic distribution in Russia. METHODS: Lung tissues from 45 Eurasian common shrews, 4 Laxmann's shrews (Sorex caecutiens), 3 Siberian large-toothed shrews (Sorex daphaenodon), 9 pygmy shrews (Sorex minutus), 28 tundra shrews (Sorex tundrensis), and 6 Siberian shrews (Crocidura sibirica), captured in 11 localities in Western and Eastern Siberia during June 2007 to September 2008, were analyzed for hantavirus RNA by reverse transcription-polymerase chain reaction. RESULTS: Hantavirus L and S segment sequences, detected in 11 S. araneus, 2 S. tundrensis, and 2 S. daphaenodon, were closely related to SWSV, differing from the prototype mp70 strain by 16.3-20.2% at the nucleotide level and 1.4-1.7% at the amino acid level. Alignment and comparison of nucleotide and amino acid sequences showed an intrastrain difference of 0-11.0% and 0% for the L segment and 0.2-8.5% and 0% for the S segment, respectively. Phylogenetic analysis, using neighbor-joining, maximum-likelihood, and Bayesian methods, showed geographic-specific clustering of SWSV strains in Western and Eastern Siberia. CONCLUSIONS: This is the first definitive report of shrew-borne hantaviruses in Siberia, and demonstrates the impressive distribution of SWSV among phylogenetically related Sorex species. Coevolution and local adaptation of SWSV genetic variants in specific chromosomal races of S. araneus may account for their geographic distribution.
Authors: M Brummer-Korvenkontio; A Vaheri; T Hovi; C H von Bonsdorff; J Vuorimies; T Manni; K Penttinen; N Oker-Blom; J Lähdevirta Journal: J Infect Dis Date: 1980-02 Impact factor: 5.226
Authors: Olli Vapalahti; Jukka Mustonen; Ake Lundkvist; Heikki Henttonen; Alexander Plyusnin; Antti Vaheri Journal: Lancet Infect Dis Date: 2003-10 Impact factor: 25.071
Authors: Hae Ji Kang; Shannon N Bennett; Laarni Sumibcay; Satoru Arai; Andrew G Hope; Gabor Mocz; Jin-Won Song; Joseph A Cook; Richard Yanagihara Journal: PLoS One Date: 2009-07-07 Impact factor: 3.240
Authors: Liudmila N Yashina; Sergey A Abramov; Tamara A Dupal; Galina A Danchinova; Boris S Malyshev; John Hay; Se Hun Gu; Richard Yanagihara Journal: Infect Genet Evol Date: 2015-05-21 Impact factor: 3.342
Authors: Matthew T Milholland; Iván Castro-Arellano; Gerardo Suzán; Gabriel E Garcia-Peña; Thomas E Lee; Rodney E Rohde; A Alonso Aguirre; James N Mills Journal: Ecohealth Date: 2018-04-30 Impact factor: 3.184
Authors: Hae Ji Kang; Satoru Arai; Andrew G Hope; Joseph A Cook; Richard Yanagihara Journal: Vector Borne Zoonotic Dis Date: 2010-08 Impact factor: 2.133
Authors: Satoru Arai; Hae Ji Kang; Se Hun Gu; Satoshi D Ohdachi; Joseph A Cook; Liudmila N Yashina; Keiko Tanaka-Taya; Sergey A Abramov; Shigeru Morikawa; Nobuhiko Okabe; Kazunori Oishi; Richard Yanagihara Journal: Vector Borne Zoonotic Dis Date: 2016-05-12 Impact factor: 2.133
Authors: Se Hun Gu; Janusz Hejduk; Janusz Markowski; Hae Ji Kang; Marcin Markowski; Małgorzata Połatyńska; Beata Sikorska; Paweł P Liberski; Richard Yanagihara Journal: Infect Genet Evol Date: 2014-10-27 Impact factor: 3.342
Authors: Mathias Schlegel; Lukáš Radosa; Ulrike M Rosenfeld; Sabrina Schmidt; Cornelia Triebenbacher; Paul-Walter Löhr; Dieter Fuchs; Marta Heroldová; Eva Jánová; Michal Stanko; Ladislav Mošanský; Jana Fričová; Milan Pejčoch; Josef Suchomel; Luboš Purchart; Martin H Groschup; Detlev H Krüger; Boris Klempa; Rainer G Ulrich Journal: Virus Genes Date: 2012-03-31 Impact factor: 2.332
Authors: Hae Ji Kang; Satoru Arai; Andrew G Hope; Jin-Won Song; Joseph A Cook; Richard Yanagihara Journal: Virol J Date: 2009-11-24 Impact factor: 4.099