Literature DB >> 20421027

Failure to perform cholecystectomy for acute cholecystitis in elderly patients is associated with increased morbidity, mortality, and cost.

Taylor S Riall1, Dong Zhang, Courtney M Townsend, Yong-Fang Kuo, James S Goodwin.   

Abstract

BACKGROUND: Cholecystectomy during initial hospitalization is the current recommended therapy for acute cholecystitis. The rate of cholecystectomy and subsequent health care trajectory in elderly patients with acute cholecystitis has not been evaluated. STUDY
DESIGN: We used 5% national Medicare sample claims data from 1996 to 2005 to identify a cohort of patients aged 66 years and older, requiring urgent or emergent admission for acute cholecystitis. We evaluated cholecystectomy rates on initial hospitalization, factors independently predicting receipt of cholecystectomy, factors predicting further gallstone-related complications, and 2-year survival in the cholecystectomy and no cholecystectomy groups in univariate and multivariate models.
RESULTS: There were 29,818 Medicare beneficiaries who were urgently or emergently admitted for acute cholecystitis from 1996 to 2005. Mean age was 77.7 +/- 7.3 years, 89% of patients were white, and 58% were female. Twenty-five percent of patients did not undergo cholecystectomy during the index admission. Lack of definitive therapy was associated with a 27% subsequent cholecystectomy rate and a 38% gallstone-related readmission rate in the 2 years after discharge; the readmission rate was only 4% in patients undergoing cholecystectomy (p < 0.0001). No cholecystectomy on initial hospitalization was associated with worse 2-year survival (hazard ratio 1.56, 95% CI 1.47 to 1.65) even after controlling for patient demographics and comorbidities. Readmissions led to an additional $7,000 in Medicare payments per readmission.
CONCLUSIONS: Our study demonstrated that 25% of cholecystectomies on Medicare beneficiaries were not performed on initial hospitalization, leading to readmissions in 38% of surviving patients. For patients requiring readmission, the percentage of open procedures was increased, and the additional Medicare payment was $7,000 per re-admission. Cholecystectomy for acute cholecystitis in elderly patients should be performed during initial hospitalization to prevent recurrent episodes of cholecystitis, multiple readmissions, higher readmission rates, and increased costs. Copyright 2010 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID: 20421027      PMCID: PMC2866125          DOI: 10.1016/j.jamcollsurg.2009.12.031

Source DB:  PubMed          Journal:  J Am Coll Surg        ISSN: 1072-7515            Impact factor:   6.113


  29 in total

1.  Controlled clinical trial comparing early with interval cholecystectomy for acute cholecystitis.

Authors:  P McArthur; A Cuschieri; R Shields; R A Sells
Journal:  Proc R Soc Med       Date:  1975-11

2.  Prospective evaluation of early versus delayed laparoscopic cholecystectomy for treatment of acute cholecystitis.

Authors:  C F Chandler; J S Lane; P Ferguson; J E Thompson; S W Ashley
Journal:  Am Surg       Date:  2000-09       Impact factor: 0.688

3.  Management of acute cholecystitis in the laparoscopic era: results of a prospective, randomized clinical trial.

Authors:  Mikael Johansson; A Thune; A Blomqvist; L Nelvin; L Lundell
Journal:  J Gastrointest Surg       Date:  2003 Jul-Aug       Impact factor: 3.452

4.  Racial disparities in cholecystectomy rates during hospitalizations for acute gallstone pancreatitis: a national survey.

Authors:  Geoffrey C Nguyen; Anne Tuskey; Sanjay B Jagannath
Journal:  Am J Gastroenterol       Date:  2008-09       Impact factor: 10.864

5.  Cholecystectomy in the elderly: a prospective study.

Authors:  P W Houghton; L R Jenkinson; L A Donaldson
Journal:  Br J Surg       Date:  1985-03       Impact factor: 6.939

6.  Early or delayed cholecystectomy in acute cholecystitis? A clinical trial.

Authors:  S Norrby; P Herlin; T Holmin; R Sjödahl; C Tagesson
Journal:  Br J Surg       Date:  1983-03       Impact factor: 6.939

7.  Laparoscopic cholecystectomy in the elderly: a prospective study.

Authors:  P Pessaux; J J Tuech; N Derouet; C Rouge; N Regenet; J P Arnaud
Journal:  Surg Endosc       Date:  2000-11       Impact factor: 4.584

8.  Consequences of prolonged wait before gallbladder surgery.

Authors:  C V N Cheruvu; I A Eyre-Brook
Journal:  Ann R Coll Surg Engl       Date:  2002-01       Impact factor: 1.891

9.  Acute cholecystitis treated by early and delayed surgery. A controlled clinical trial.

Authors:  J Lahtinen; E M Alhava; S Aukee
Journal:  Scand J Gastroenterol       Date:  1978       Impact factor: 2.423

10.  The natural history of silent gallstones: the innocent gallstone is not a myth.

Authors:  W A Gracie; D F Ransohoff
Journal:  N Engl J Med       Date:  1982-09-23       Impact factor: 91.245

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  51 in total

1.  Laparoscopic approach to acute abdomen from the Consensus Development Conference of the Società Italiana di Chirurgia Endoscopica e nuove tecnologie (SICE), Associazione Chirurghi Ospedalieri Italiani (ACOI), Società Italiana di Chirurgia (SIC), Società Italiana di Chirurgia d'Urgenza e del Trauma (SICUT), Società Italiana di Chirurgia nell'Ospedalità Privata (SICOP), and the European Association for Endoscopic Surgery (EAES).

Authors:  Ferdinando Agresta; Luca Ansaloni; Gian Luca Baiocchi; Carlo Bergamini; Fabio Cesare Campanile; Michele Carlucci; Giafranco Cocorullo; Alessio Corradi; Boris Franzato; Massimo Lupo; Vincenzo Mandalà; Antonino Mirabella; Graziano Pernazza; Micaela Piccoli; Carlo Staudacher; Nereo Vettoretto; Mauro Zago; Emanuele Lettieri; Anna Levati; Domenico Pietrini; Mariano Scaglione; Salvatore De Masi; Giuseppe De Placido; Marsilio Francucci; Monica Rasi; Abe Fingerhut; Selman Uranüs; Silvio Garattini
Journal:  Surg Endosc       Date:  2012-06-27       Impact factor: 4.584

2.  Cost utility of early versus delayed laparoscopic cholecystectomy for acute cholecystitis.

Authors:  Amanda Johner; Adam Raymakers; Sam M Wiseman
Journal:  Surg Endosc       Date:  2012-07-07       Impact factor: 4.584

3.  CAGS and ACS Evidence Based Reviews in Surgery. 41. Cost-utility analysis of early versus delayed laparoscopic cholecystectomy for acute cholecystitis.

Authors:  Elijah Dixon; Dennis L Fowler; Gabriela Ghitulescu
Journal:  Can J Surg       Date:  2012-06       Impact factor: 2.089

4.  An observational study of the timing of surgery, use of laparoscopy and outcomes for acute cholecystitis in the USA and UK.

Authors:  A C Murray; S Markar; H Mackenzie; O Baser; T Wiggins; A Askari; G Hanna; O Faiz; E Mayer; C Bicknell; A Darzi; R P Kiran
Journal:  Surg Endosc       Date:  2018-01-08       Impact factor: 4.584

5.  The risk paradox: use of elective cholecystectomy in older patients is independent of their risk of developing complications.

Authors:  Taylor S Riall; Deepak Adhikari; Abhishek D Parmar; Suzanne K Linder; Francesca M Dimou; Winston Crowell; Nina P Tamirisa; Courtney M Townsend; James S Goodwin
Journal:  J Am Coll Surg       Date:  2014-12-17       Impact factor: 6.113

6.  What is the effect of treatment modality on red blood cell distribution width in patients with acute cholecystitis?

Authors:  Pınar Yazıcı; Uygar Demir; Emre Bozdağ; Emre Bozkurt; Gürhan Işıl; Özgür Bostancı; Mehmet Mihmanlı
Journal:  Ulus Cerrahi Derg       Date:  2015-03-01

7.  Long-term outcome of patients with acute cholecystitis receiving antibiotic treatment: a retrospective cohort study.

Authors:  Chih-Hung Wang; Hao-Chang Chou; Kao-Lang Liu; Wan-Ching Lien; Hsiu-Po Wang; Yao-Ming Wu
Journal:  World J Surg       Date:  2014-02       Impact factor: 3.352

Review 8.  Laparoscopic cholecystectomy: consensus conference-based guidelines.

Authors:  Ferdinando Agresta; Fabio Cesare Campanile; Nereo Vettoretto; Gianfranco Silecchia; Carlo Bergamini; Pietro Maida; Pietro Lombari; Piero Narilli; Domenico Marchi; Alessandro Carrara; Maria Grazia Esposito; Stefania Fiume; Giuseppe Miranda; Simona Barlera; Marina Davoli
Journal:  Langenbecks Arch Surg       Date:  2015-04-08       Impact factor: 3.445

9.  Androgen-deprivation therapy and risk for biliary disease in men with prostate cancer.

Authors:  Philip J Saylor; Matthew R Smith; A James O'Malley; Nancy L Keating
Journal:  Eur Urol       Date:  2013-02-12       Impact factor: 20.096

Review 10.  Evidence-based clinical practice guidelines for cholelithiasis 2016.

Authors:  Susumu Tazuma; Michiaki Unno; Yoshinori Igarashi; Kazuo Inui; Kazuhisa Uchiyama; Masahiro Kai; Toshio Tsuyuguchi; Hiroyuki Maguchi; Toshiyuki Mori; Koji Yamaguchi; Shomei Ryozawa; Yuji Nimura; Naotaka Fujita; Keiichi Kubota; Junichi Shoda; Masami Tabata; Tetsuya Mine; Kentaro Sugano; Mamoru Watanabe; Tooru Shimosegawa
Journal:  J Gastroenterol       Date:  2016-12-10       Impact factor: 7.527

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